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Displaying results 111 - 120 of 7187 in total
  1. Drug

    Florquinitau (18F)

    go.drugbank.com/drugs/DB19215
    ApprovedInvestigational

    [L64052] It binds to aggregated tau protein, which in Alzheimer's disease forms the neurofibrillary tangles (NFTs) that are one of the two components required for a neuropathological diagnosis of the disease … Florquinitau F 18 is a radioactive diagnostic drug used as a fluorine-18–labeled positron emission tomography (PET) tracer.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesSynonyms: 6-fluoro-3-(1h-pyrrolo(2,3-c)pyridin-1-yl)isoquinolin-5-amine, 5-isoquinolinamine, 6-(fluoro-18f)-3-(1h-pyrrolo(2,3-c)pyridin-1-yl)-
  2. Target

    Pyrroloquinoline-quinone synthase

    go.drugbank.com/bio_entities/BE0003016
    TargetKlebsiella pneumoniae

    Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.

    Synonyms: Coenzyme PQQ synthesis protein C, Pyrroloquinoline quinone biosynthesis protein C
  3. Target

    Serine/threonine-protein kinase N1

    go.drugbank.com/bio_entities/BE0009520
    TargetHumans

    Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. … PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription

    Polypeptides: Serine/threonine-protein kinase N1Synonyms: Protein kinase C-like 1, Protein kinase C-like PKN
  4. Target

    Protein S100-A11

    go.drugbank.com/bio_entities/BE0002789
    TargetHumans

    Facilitates the differentiation and the cornification of keratinocytes

    Polypeptides: Protein S100-A11Synonyms: Protein S100-C, S100 calcium-binding protein A11
  5. Target

    Penicillin-binding protein 3

    go.drugbank.com/bio_entities/BE0000790
    TargetBacillus subtilis (strain 168)

    Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis (Probable). Probably required for both cortical and vegetative peptidoglycan synthesis (Probable).

    Polypeptides: Penicillin-binding protein 3Synonyms: Penicillin-binding protein C
  6. Target

    Porin

    go.drugbank.com/bio_entities/BE0003941
    TargetTransporterEscherichia coli

    Synonyms: Outer membrane protein C, Membrane protein
  7. Target

    Small ribosomal subunit protein RACK1

    go.drugbank.com/bio_entities/BE0008967
    TargetHumans

    Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. … Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A.

    Polypeptides: Small ribosomal subunit protein RACK1Synonyms: Receptor of activated protein C kinase 1, Guanine nucleotide-binding protein subunit beta-like protein 12.3
  8. Target

    Coagulation factor V

    go.drugbank.com/bio_entities/BE0000041
    TargetCarrierHumans

    Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin

    Synonyms: Activated protein C cofactor
  9. Target

    UDP-N-acetylglucosamine 2-epimerase

    go.drugbank.com/bio_entities/BE0001428
    TargetEscherichia coli (strain K12)

    Catalyzes the reversible epimerization at C-2 of UDP-N-acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues.

    Synonyms: Bacteriophage N4 adsorption protein CFunction: protein homodimerization activity
  10. Target

    Serine/threonine-protein kinase D1

    go.drugbank.com/bio_entities/BE0009525
    TargetHumans

    Acts downstream of the heterotrimeric G protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway … Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS).

    Polypeptides: Serine/threonine-protein kinase D1Synonyms: Protein kinase C mu type, Protein kinase D