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Amisulpride Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126531Drug actionAmisulpride, a substituted benzamide derivative, is a second-generation (atypical) antipsychotic. Amisulpride is a selective dopamine D2 and D3 receptor antagonist with no affinity towards other dopamine receptor subtypes. At low doses, ...
Enzymes: Sodium-dependent serotonin transporterAcepromazine - Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126586Drug actionAcepromazine is a phenothiazine tranquilizer that blocks dopamine receptors in the CNS and depresses the reticular-activating system, resulting in sedation. Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It...
Enzymes: Sodium-dependent serotonin transporterRotigotine Dopamine Agonist Action Pathway
smpdb.ca/view/SMP0126641Drug actionRotigotine is an agonist at all 5 dopamine receptor subtypes (D1-D5) but binds to the D3 receptor with the highest affinity. It is delivered continuously through the skin (transdermal) using a silicone-based patch that is replaced every ...
Enzymes: Sodium-dependent dopamine transporterBrexpiprazole Serotonin Action Action Pathway
smpdb.ca/view/SMP0126699Drug actionAlthough the exact mechanism of action of brexpiprazole in psychiatric disorders has not been fully elucidated, the efficacy of brexpiprazole may be attributed to combined partial agonist activity at 5-HT1A and dopamine D2 receptors, and...
Enzymes: Sodium-dependent serotonin transporterChlorpromazine - Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126487Drug actionProchlorperazine and chlorpromazine are examples of this class of Phenothiazines. Phenothiazines antagonize the D2 receptor, most notably in the area postrema in the brain. IV, PO, and rectal (PR) formulations are available. Side effects...
Enzymes: Sodium-dependent serotonin transporterAmoxapine SSRI Action Pathway
smpdb.ca/view/SMP0126502Drug actionAmoxapine is a second-generation tricyclic dibenzoxazepine antidepressant, chemically distinct from the dibenzodiazepines, dibenzocycloheptenes, and dibenzoxepines. It has a mild sedative component to its action. The mechanism of its cli...
Enzymes: Sodium-dependent serotonin transporterChlorprothixene Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126577Drug actionChlorprothixene is a thioxanthene antipsychotic. Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the ...
Enzymes: Sodium-dependent dopamine transporterZuclopenthixol Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126579Drug actionZuclopenthixol, also known as Zuclopentixol or Zuclopenthixolum, is an antipsychotic agent. Zuclopenthixol is a thioxanthene-based neuroleptic with therapeutic actions similar to the phenothiazine antipsychotics. Zuclopenthixol is a typi...
Enzymes: Sodium-dependent dopamine transporterCariprazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126662Drug actionCariprazine is indicated for the treatment of schizophrenia in adults to manage both positive and negative symptoms. It is also indicated to monotherapy for acute management of manic or mixed episodes associated with bipolar I disorder (...
Enzymes: Sodium-dependent dopamine transporterFlibanserin Serotonin Action Action Pathway
smpdb.ca/view/SMP0126786Drug actionFlibansetrin has high affinity for serotonin receptors in the brain: it acts as an agonist on 5-HT1A and an antagonist on 5-HT2A. In vivo, flibanserin binds equally to 5-HT1A and 5-HT2A receptors. However, under higher levels of brain 5-...
Enzymes: Sodium-dependent serotonin transporter