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Dipivefrin A2-Adrenergic Vasocontriction Action Pathway
smpdb.ca/view/SMP0126098Drug actionDipivefrin is a prodrug of epinephrine used in ophthalmic solutions to reduce intraocular pressure in chronic open-angle glaucoma. It is available as ophthalmic solution (eye drops). Dipivefrin is a prodrug with little or no pharmacologi...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Fenobam
go.drugbank.com/drugs/DB12931InvestigationalFenobam is under investigation in clinical trial NCT00637221 (Open Label Study Investigating Safety and Efficacy of Fenobam anhydrous 50 mg - 150 mg on Prepulse Inhibition Tests and Continuous Performance … Tasks, Adults With Fragile X Syndrome).
Categories: Heterocyclic Compounds, 1-RingDavesomeran
go.drugbank.com/drugs/DB17091ApprovedInvestigational[L43882] A phase 2 and 3 open-label study in participants 18 years or older who had previously received a two-dose primary series and one booster dose of Moderna COVID-19 Vaccine demonstrated that the … Similar to the previous Moderna COVID-19 vaccine, Moderna Bivalent vaccine encodes the full-length pre-fusion stabilized spike (S) protein to elicit an immune response.
Mixtures: Spikevax Bivalent (original / Omicron Ba.4/5)Triplizumab
go.drugbank.com/drugs/DB30669Investigationaltriplizumab is a biologic drug. triplizumab is under investigation in clinical trial NCT06486220 (PFLL Combined With PD-1 Antibody With or Without FMT for Oligometastatic NPC,a Phase III ,Open, Randomized
Pergolide Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126635Drug actionThe dopamine D2 receptor is a 7-transmembrane G-protein coupled receptor associated with Gi proteins. In lactotrophs, stimulation of dopamine D2 receptor causes inhibition of adenylyl cyclase, which decreases intracellular cAMP concentra...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortPembrolizumab
go.drugbank.com/drugs/DB09037ApprovedInvestigational[F136] It was developed by Merck & Co and first approved for the treatment of metastatic malignant melanoma by the FDA on September 4, 2014,[L2954] becoming the first approved therapy against PD-1. … Pembrolizumab is a highly selective IgG4-kappa humanized monoclonal antibody against PD-1 receptors.
Categories: PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsProducts: Keytruda Sc, KEYTRUDA SCFomivirsen
go.drugbank.com/drugs/DB06759ApprovedWithdrawnFomivirsen is a antisense 21 mer phosphorothioate oligonucleotide. … As a complementary nucleotide to the messenger RNA of the major immediate-early region proteins of human cytomegalovirus, it disrupts the replication of the virus through an antisense mechanism [L1428]
Categories: Compounds used in a research, industrial, or household settingDoconexent
go.drugbank.com/drugs/DB03756ApprovedInvestigationalA mixture of fish oil and primrose oil, doconexent is used as a high-docosahexaenoic acid (DHA) supplement. DHA is a 22 carbon chain with 6 cis double bonds with anti-inflammatory effects. … It is an omega-3 fatty acid and primary structural component of the human brain, cerebral cortex, skin, and retina thus plays an important role in their development and function.
Mixtures: Se-Tan DHA, Se-Plete DHACategories: Fatty Acids, Omega-3, Cytochrome P-450 SubstratesPovidone
go.drugbank.com/drugs/DB11061ApprovedInvestigationalWithdrawnimpaired wound healing, reduced wound strength, or infection in open wounds [A32988]. … Povidone, also known as polyvinylpyrrolidone (PVP) or polyvidone, is a synthetic water-soluble polymer made from the monomer N-vinylpyrrolidone used as a binder in many pharmaceutical tablets and lubricant
Mixtures: SK Advanced Relief Eye Drops, Murine Tears 1Categories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household settingPAS-004
go.drugbank.com/drugs/DB18611InvestigationalPAS-004 is an allosteric MEK 1/2 inhibitor being developed by Pasithea Therapeutics. It is being investigated for the treatment of neurofibromatosis 1 and Noonan syndrome.