Search

Displaying results 1211 - 1220 of 10000 in total
  1. Drug

    Calcium ascorbate

    go.drugbank.com/drugs/DB14483
    ApprovedNutraceutical

    Mixtures: Supplements De Vitamines Et Mineraux, Se-Vate 21/7
  2. Target

    Nuclear receptor subfamily 0 group B member 1

    go.drugbank.com/bio_entities/BE0000074
    TargetHumans

    Nuclear receptor that lacks a DNA-binding domain and acts as a corepressor that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions (PubMed:12482977, PubMed

    Polypeptides: Nuclear receptor subfamily 0 group B member 1Synonyms: Nuclear receptor DAX-1
  3. Target

    Nuclear receptor subfamily 1 group D member 1

    go.drugbank.com/bio_entities/BE0009347
    TargetHumans

    Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. … Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced

    Polypeptides: Nuclear receptor subfamily 1 group D member 1
  4. Target

    Leucine-rich repeat serine/threonine-protein kinase 2

    go.drugbank.com/bio_entities/BE0009457
    TargetHumans

    Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent

    Polypeptides: Leucine-rich repeat serine/threonine-protein kinase 2
  5. Target

    Tyrosine-protein phosphatase non-receptor type substrate 1

    go.drugbank.com/bio_entities/BE0010650
    TargetHumans

    Receptor for THBS1 (PubMed:24511121). Interaction with THBS1 stimulates phosphorylation of SIRPA (By similarity). … Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin.

    Polypeptides: Tyrosine-protein phosphatase non-receptor type substrate 1Synonyms: Inhibitory receptor SHPS-1, Macrophage fusion receptor
  6. Target

    F-box-like/WD repeat-containing protein TBL1X

    go.drugbank.com/bio_entities/BE0012106
    TargetHumans

    F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219).

    Polypeptides: F-box-like/WD repeat-containing protein TBL1X
  7. Drug

    Dexchlorpheniramine maleate

    go.drugbank.com/drugs/DB09555
    Approved

    Dexchlorpheniramine has more pharmacological activity than the R and so is more potent than the racemic mixture. … Dexchlorpheniramine is the S-enantiomer of chlorpheniramine which is a 1st generation anti-histamine.

    Mixtures: Re Drylex, Corzall PE
  8. Drug

    Susoctocog alfa

    go.drugbank.com/drugs/DB11606
    ApprovedInvestigational

    In a global, prospective, controlled, multi-center Phase 2/3 open-label clinical trial, all patients responded to susoctocog alfa treatment within 24 hours [L1129]. … It is the first recombinant porcine FVIII treatment approved for AHA that allows physicians to manage the treatment's efficacy and safety by measuring factor VIII activity levels in addition to clinical

  9. Target

    Nuclear receptor subfamily 1 group I member 2

    go.drugbank.com/bio_entities/BE0000956
    TargetHumans

    Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. … Upon ligand binding, translocates to the nucleus, forms a heterodimer with the retinoid X receptor/RXR, and binds to response elements in target promoters, leading to transcriptional activation.

    Polypeptides: Nuclear receptor subfamily 1 group I member 2Synonyms: Pregnane X receptor, Orphan nuclear receptor PAR1
  10. Target

    Gamma-aminobutyric acid type B receptor subunit 2

    go.drugbank.com/bio_entities/BE0002340
    TargetHumans

    Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating … Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688).

    Polypeptides: Gamma-aminobutyric acid type B receptor subunit 2Synonyms: GABA-B receptor 2, G protein-coupled receptor 51