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Displaying results 1251 - 1260 of 10000 in total
  1. Drug

    Siponimod

    go.drugbank.com/drugs/DB12371
    ApprovedInvestigational

    Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. … Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings.

    Categories: Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
  2. Drug

    Bromocriptine

    go.drugbank.com/drugs/DB01200
    ApprovedInvestigationalWithdrawn

    It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. … Bromocriptine has been associated with pulmonary fibrosis, and can also cause sustained suppression of somatotropin (growth hormone) secretion in some patients with acromegaly.

    Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: 2-bromo-α-ergokryptin, 2-bromo-α-ergocryptine
  3. Drug

    Thiothixene

    go.drugbank.com/drugs/DB01623
    Approved

    A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 3-Ring
  4. Drug

    Cyclobenzaprine

    go.drugbank.com/drugs/DB00924
    ApprovedInvestigational

    [A185039,A184982] Since its approval, it has remained relatively popular as an adjunctive, short-term treatment for acute skeletal muscle spasms secondary to musculoskeletal injury. … Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961[A185039] and has been available for human use since 1977.

    Mixtures: Cyclo/Mag, Cyclo/Mag 10mg/200mgCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  5. Drug

    Asciminib

    go.drugbank.com/drugs/DB12597
    ApprovedInvestigational

    More specifically, it is an inhibitor of the ABL1 kinase activity of the BCR-ABL1 fusion protein[L38995] which serves as a driver of CML proliferation in most patients with the disease. … [A241065] Asciminib is unique in that it acts as an allosteric inhibitor, binding at the myristoyl pocket of the BCR-ABL1 protein and locking it into an inactive conformation.

    Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
  6. Drug

    Drometrizole trisiloxane

    go.drugbank.com/drugs/DB11585
    Approved

    Drometrizole trisiloxane is a photostable UVA and UVB light filter [A33069, L2780, L2781, L2782, L2783, F81]. … The compound is a lipophilic benzotriazole derivative marketed as Meroxyl XL by L'Oreal, although sunscreens with drometrizole trisiloxane are currently only approved for use in the EU, Canada, Australia

    Mixtures: Garnier Ombrelle Kids Wet N Protect Hypoallergenic SPF 45 Mexoryl Technology, Garnier Ombrelle Kids Wet N Protect Hypoallergenic SPF 45 Mexoryl TechnologyCategories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household setting
  7. Drug

    Trioxsalen

    go.drugbank.com/drugs/DB04571
    ApprovedWithdrawn

    In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage.[3] The compound is has been explored for development of antisense oligonucleotides that can be … cross-linked specifically to a mutant mRNA sequence without affecting normal transcripts differing at even a single base pair.

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: 6-hydroxy-β,2,7-trimethyl-5-benzofuranacrylic acid, δ-lactone, 2',4,8-Trimethylpsoralen
  8. Drug

    Auranofin

    go.drugbank.com/drugs/DB00995
    ApprovedInvestigational

    Heme oxygenase 1 is an inducible heme-degrading enzyme with anti-inflammatory properties. … It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA.

    Synonyms: 2,3,4,6-Tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S (triethylphosphine)gold, (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate
  9. Drug

    Potassium sulfate

    go.drugbank.com/drugs/DB14499
    Approved

    Mixtures: VINATAL DHA CAPSULA DE GELATINA BLANDA, Mega Min Capsules
  10. Drug

    Prothrombin

    go.drugbank.com/drugs/DB11311
    ApprovedInvestigational

    Prothrombin Complex Concentrate (Human), is indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with

    Mixtures: UMAN COMPLEX, UMAN COMPLEX