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Branaplam
go.drugbank.com/drugs/DB14918InvestigationalBranaplam is under investigation in clinical trial NCT02268552 (An Open Label Study of LMI070 (Branaplam) in Type 1 Spinal Muscular Atrophy (SMA)).
Elasomeran
go.drugbank.com/drugs/DB15654ApprovedInvestigational[L28026] A phase I, open-label, dose-ranging clinical trial (NCT04283461) was initiated in March 2020 in which 45 subjects received two intramuscular doses (on days 1 and 29). … [L39217] The Moderna COVID-19 Vaccine was fully approved by the FDA on January 31, 2022 [L40079] and Health Canada expanded the use of the Moderna COVID-19 Vaccine to include individuals aged six to 11
Atenolol
go.drugbank.com/drugs/DB00335ApprovedInvestigationalLater they continued to be investigated for use in heart failure throughout the 1970-1980s. … Sir James Black, a Scottish pharmacologist, pioneered the use of beta-blockers for the management of angina pectoris in 1958 for which he received the Nobel Prize.
Mixtures: NIF TEN 50, NIF-TEN CAPSULECategories: Adrenergic beta-1 Receptor AntagonistsTransient receptor potential cation channel subfamily A member 1
go.drugbank.com/bio_entities/BE0001122TargetHumansAlso acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312).
Polypeptides: Transient receptor potential cation channel subfamily A member 1Synonyms: Wasabi receptorTransient receptor potential cation channel subfamily M member 8
go.drugbank.com/bio_entities/BE0001186TargetHumansNon-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolal...
Polypeptides: Transient receptor potential cation channel subfamily M member 8Synonyms: Transient receptor potential p8, Long transient receptor potential channel 6Low affinity immunoglobulin gamma Fc region receptor III-A
go.drugbank.com/bio_entities/BE0002097TargetHumansReceptor for the invariable Fc fragment of immunoglobulin gamma (IgG). … The ITAM-dependent signaling coupled to receptor phosphorylation by PKC mediates robust intracellular calcium flux that leads to production of pro-inflammatory cytokines, whereas in the absence of receptor
Polypeptides: Low affinity immunoglobulin gamma Fc region receptor III-ASynonyms: IgG Fc receptor III-2, IgG Fc receptor III-ALow affinity immunoglobulin gamma Fc region receptor II-c
go.drugbank.com/bio_entities/BE0002100TargetHumansReceptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor.
Polypeptides: Low affinity immunoglobulin gamma Fc region receptor II-cSynonyms: IgG Fc receptor II-cTransient receptor potential cation channel subfamily V member 3
go.drugbank.com/bio_entities/BE0003416TargetHumansNon-selective calcium permeant cation channel (PubMed:12077604, PubMed:12077606, PubMed:26818531, PubMed:37648856, PubMed:38691614). It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures...
Polypeptides: Transient receptor potential cation channel subfamily V member 3Synonyms: Vanilloid receptor-like 3Transient receptor potential cation channel subfamily M member 7
go.drugbank.com/bio_entities/BE0004624TargetTransporterHumansBifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The...
Polypeptides: Transient receptor potential cation channel subfamily M member 7Synonyms: Long transient receptor potential channel 7Transient receptor potential cation channel subfamily V member 5
go.drugbank.com/bio_entities/BE0005112TransporterHumansConstitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubu...
Polypeptides: Transient receptor potential cation channel subfamily V member 5