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Gamma-aminobutyric acid receptor subunit gamma-2
go.drugbank.com/bio_entities/BE0003592TargetHumansGABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner (By similarity)
Polypeptides: Gamma-aminobutyric acid receptor subunit gamma-2Synonyms: GABA(A) receptor subunit gamma-2Gamma-aminobutyric acid receptor subunit rho-2
go.drugbank.com/bio_entities/BE0003598TargetHumansRho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (By similarity). Rho-containing GABA-gated chloride ...
Polypeptides: Gamma-aminobutyric acid receptor subunit rho-2Synonyms: GABA(C) receptor, GABA(A) receptor subunit rho-2Acetylcholine receptor subunit beta-type unc-29
go.drugbank.com/bio_entities/BE0004928TargetCaenorhabditis elegansNon-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine and levasimole.
Polypeptides: Acetylcholine receptor subunit beta-type unc-29Receptor-interacting serine/threonine-protein kinase 2
go.drugbank.com/bio_entities/BE0009532TargetHumansAlso involved in adaptive immunity: plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (PubMed:14638696).
Polypeptides: Receptor-interacting serine/threonine-protein kinase 2Synonyms: Receptor-interacting protein 2Tyrosine-protein phosphatase non-receptor type 6
go.drugbank.com/bio_entities/BE0009941TargetHumansModulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). … Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788).
Polypeptides: Tyrosine-protein phosphatase non-receptor type 6Tumor necrosis factor receptor superfamily member 17
go.drugbank.com/bio_entities/BE0010010TargetHumansReceptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK
Polypeptides: Tumor necrosis factor receptor superfamily member 17Function: signaling receptor activityC-X-C chemokine receptor type 2
go.drugbank.com/bio_entities/BE0010516TargetHumansReceptor for interleukin-8 which is a powerful neutrophil chemotactic factor (PubMed:1891716). Binding of IL-8 to the receptor causes activation of neutrophils.
Polypeptides: C-X-C chemokine receptor type 2Synonyms: GRO/MGSA receptor, IL-8 receptor type 2Tumor necrosis factor receptor superfamily member 16
go.drugbank.com/bio_entities/BE0010540TargetHumansLow affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. … Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487).
Polypeptides: Tumor necrosis factor receptor superfamily member 16Synonyms: NGF receptor, Low affinity neurotrophin receptor p75NTRAntiviral innate immune response receptor RIG-I
go.drugbank.com/bio_entities/BE0012418TargetHumansInnate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines (PubMed:15208624
Polypeptides: Antiviral innate immune response receptor RIG-ISynonyms: RIG-I-like receptor 1Tumor necrosis factor receptor superfamily member 13C
go.drugbank.com/bio_entities/BE0018598TargetHumansB-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response
Polypeptides: Tumor necrosis factor receptor superfamily member 13CSynonyms: BAFF receptor, BLyS receptor 3