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Displaying results 121 - 130 of 134683 in total
  1. Pathway

    Carbamazepine Sodium Channel Analgesic Action Pathway

    smpdb.ca/view/SMP0123059
    Drug action

    In neurons that are repetitively firing, their sodium channels are being opened more often, and as a result, carbamazepine is able to produce a greater block in these neurons. … By blocking the voltage gated sodium channels, carbamazepine prevents the depolarization phase, inhibiting action potential generation and the release of excitatory neurotransmitter like glutamate.

    Drugs: Carbamazepine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-2, Sodium channel subunit beta-1
  2. Pathway

    Tocainide Sodium Channel Antiepileptic Action Pathway

    smpdb.ca/view/SMP0126266
    Drug action

    Tocainide is an orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels and typically used to treat ventricular arrhythmias. … In neurons that are repetitively firing, their sodium channels are being opened more often, and as a result, tocainide is able to produce a greater block in these neurons.

    Drugs: Tocainide · Potassium cation · Calcium
    Enzymes: Sodium channel protein type 5 subunit alpha
  3. Pathway

    Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126504
    Drug action

    Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. … , conduction rate, and force of contraction.

    Drugs: Lidocaine · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Sodium channel subunit beta-1
  4. Pathway

    Tocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126519
    Drug action

    Tocainide is an orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels and typically used to treat ventricular arrhythmias. … Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells.

    Drugs: Tocainide · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Sodium channel protein type 5 subunit alpha
  5. Pathway

    D-Glyceric Aciduria

    smpdb.ca/view/SMP0125705
    Disease

    D-Glyceric aciduria is an extremely rare inherited inborn error of metabolism (IEM) of serine and fructose metabolism. … Defects in the enzyme will lead to accumulations of D-glyceric acid in tissues and biofluids.

    Drugs: NADH · ATP · sn-glycerol 3-phosphate · Flavin adenine dinucleotide · Palmitic Acid · Glycerin +1 more
    Enzymes: Glycerol kinase, Glycerol-3-phosphate dehydrogenase, mitochondrial
  6. Pathway

    Sulfite Oxidase Deficiency

    smpdb.ca/view/SMP0125709
    Disease

    Sulfite oxidase deficiency (SOD) is a disorder, an autosomal recessive disease. … In classic SOD, it is usually identified a few days after the birth of an affected individual, and is recognizable through characteristic dysmorphic features, seizures, and other signs of progressive encephalopathy

    Drugs: ATP · Estrone · Magnesium cation · Mesoheme · Propyl alcohol · Phenol +2 more
    Enzymes: Sulfite oxidase, mitochondrial
  7. Pathway

    D-Glyceric Acidura

    smpdb.ca/view/SMP0000529
    Disease

    D-Glyceric aciduria is an extremely rare inherited inborn error of metabolism (IEM) of serine and fructose metabolism. … Defects in the enzyme will lead to accumulations of D-glyceric acid in tissues and biofluids.

    Drugs: NADH · ATP · sn-glycerol 3-phosphate · Flavin adenine dinucleotide · Palmitic Acid · Glycerin +1 more
    Enzymes: Glycerol kinase, Glycerol-3-phosphate dehydrogenase, mitochondrial
  8. Pathway

    Sulfite Oxidase Deficiency

    smpdb.ca/view/SMP0000532
    Disease

    Sulfite oxidase deficiency (SOD) is a disorder, an autosomal recessive disease. … In classic SOD, it is usually identified a few days after the birth of an affected individual, and is recognizable through characteristic dysmorphic features, seizures, and other signs of progressive encephalopathy

    Drugs: ATP · Estrone · Magnesium cation · Mesoheme · Propyl alcohol · Phenol +2 more
    Enzymes: Sulfite oxidase, mitochondrial
  9. Pathway

    Glycerol Kinase Deficiency

    smpdb.ca/view/SMP0000187
    Disease

    A deficiency in this enzyme results in accumulation of glycerol in urine and serum. Symptoms include cryptorchism, trabismus, myopathy, lethargy, and vomiting. … Treatment includes corticosteroids and acute glucose infusion.

    Drugs: NADH · ATP · sn-glycerol 3-phosphate · Flavin adenine dinucleotide · Palmitic Acid · Glycerin +1 more
    Enzymes: Glycerol kinase, Glycerol-3-phosphate dehydrogenase, mitochondrial
  10. Pathway

    Glycerol Kinase Deficiency

    smpdb.ca/view/SMP0125704
    Disease

    A deficiency in this enzyme results in accumulation of glycerol in urine and serum. Symptoms include cryptorchism, strabismus, myopathy, lethargy, and vomiting. … Treatment includes corticosteroids and acute glucose infusion.

    Drugs: NADH · ATP · sn-glycerol 3-phosphate · Flavin adenine dinucleotide · Palmitic Acid · Glycerin +1 more
    Enzymes: Glycerol kinase, Glycerol-3-phosphate dehydrogenase, mitochondrial