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DNA-binding protein SMUBP-2
go.drugbank.com/bio_entities/BE0013009TargetHumans5' to 3' helicase that unwinds both RNA and DNA duplexes in an ATP-dependent reaction (Probable) (PubMed:19158098, PubMed:30218034).
Synonyms: DNA and RNA 5'-3' helicase IGHMBP2Serine/threonine-protein kinase 26
go.drugbank.com/bio_entities/BE0004109TargetHumansPart of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. … STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling.
Synonyms: MST3 and SOK1-related kinaseCytohesin-3
go.drugbank.com/bio_entities/BE0004433TargetHumansPromotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity)
Synonyms: PH, SEC7 and coiled-coil domain-containing protein 3Anoctamin-1
go.drugbank.com/bio_entities/BE0004746TargetHumansActs as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. … Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment (By similarity
Synonyms: Tumor-amplified and overexpressed sequence 2Metal cation symporter ZIP14
go.drugbank.com/bio_entities/BE0009903TransporterHumansand immunity (PubMed:15642354, PubMed:27231142, PubMed:29621230). … Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions (By similarity).
Synonyms: Zrt- and Irt-like protein 14Mitogen-activated protein kinase kinase kinase 20
go.drugbank.com/bio_entities/BE0005595TargetHumansActs by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways … Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515).
Synonyms: Leucine zipper- and sterile alpha motif-containing kinase, Sterile alpha motif- and leucine zipper-containing kinase AZKSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
go.drugbank.com/bio_entities/BE0010396TargetHumansAs neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or … The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity).
Synonyms: Mitotic growth and transcription activatorGlutamate decarboxylase
go.drugbank.com/bio_entities/BE0010293TargetHumansCatalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor.
Synonyms: Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa), Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa), isoform CRA_bSerine/threonine-protein kinase DCLK2
go.drugbank.com/bio_entities/BE0009430TargetHumansProtein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. … May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity
Synonyms: Doublecortin-like and CAM kinase-like 2Hepatitis A virus cellular receptor 2
go.drugbank.com/bio_entities/BE0010551TargetHumansInhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). … Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function.
Synonyms: T-cell immunoglobulin and mucin domain-containing protein 3