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Displaying results 121 - 130 of 358 in total
  1. Target

    Cytochrome b-c1 complex subunit 9

    go.drugbank.com/bio_entities/BE0003861
    TargetHumans

    The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase … and the ATP synthase.

    Synonyms: Complex III subunit 9, Complex III subunit X
  2. Target

    NPC intracellular cholesterol transporter 2

    go.drugbank.com/bio_entities/BE0010359
    TransporterHumans

    Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (PubMed:17018531). … Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:11125141, PubMed:15937921, PubMed:17018531

    Synonyms: Human epididymis-specific protein 1
  3. Target

    Kynurenine--oxoglutarate transaminase 3

    go.drugbank.com/bio_entities/BE0002162
    TargetHumans

    Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). … May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.

    Synonyms: Kynurenine aminotransferase III, Kynurenine--oxoglutarate transaminase III
  4. Target

    Neutrophil elastase

    go.drugbank.com/bio_entities/BE0000394
    TargetEnzymeHumans

    Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG) (PubMed:25211214, PubMed … Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes (PubMed:15140022).

    Synonyms: Human leukocyte elastase
  5. Target

    Arsenite methyltransferase

    go.drugbank.com/bio_entities/BE0005015
    TargetEnzymeHumans

    Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals (PubMed:16407288, PubMed:25997655). … Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (PubMed:16407288, PubMed:25997655)

    Synonyms: S-adenosyl-L-methionine:arsenic(III) methyltransferase
  6. Target

    Cytochrome c1, heme protein, mitochondrial

    go.drugbank.com/bio_entities/BE0003854
    TargetHumans

    The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase … and the ATP synthase.

    Synonyms: Complex III subunit 4, Complex III subunit IV
  7. Target

    Cytochrome b-c1 complex subunit 8

    go.drugbank.com/bio_entities/BE0003857
    TargetHumans

    The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase … and the ATP synthase.

    Synonyms: Complex III subunit 8, Complex III subunit VIII
  8. Target

    Proton-coupled zinc antiporter SLC30A9, mitochondrial

    go.drugbank.com/bio_entities/BE0009890
    TransporterHumans

    Mitochondrial proton-coupled zinc ion antiporter mediating the export of zinc from the mitochondria and involved in zinc homeostasis, zinc mobilization as well as mitochondrial morphology and health (PubMed

    Synonyms: Human embryonic lung protein
  9. Target

    Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3

    go.drugbank.com/bio_entities/BE0011438
    TargetHumans

    , such as alpha 2,3-sialylparagloboside and ganglioside GM3 and to a lesser extent NCAM1 N-glycans (PubMed:10766765, PubMed:9826427). … Forms oligosialic and polysialic acid on various sialylated N-acetyllactosamine oligosaccharides of glycoproteins, including FETUB N-glycans, a2-HS-glycoprotein (AHSG) and alpha 2,3-sialylated glycosphingolipids

    Synonyms: hST8Sia III, Alpha-2,8-sialyltransferase III
  10. Target

    Sphingomyelin phosphodiesterase 4

    go.drugbank.com/bio_entities/BE0002300
    TargetHumans

    It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function (PubMed:31495489). … Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:16517606, PubMed:25180167).

    Synonyms: Neutral sphingomyelinase III