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Hyaluronan and proteoglycan link protein 3
go.drugbank.com/bio_entities/BE0004935TargetHumansMay function in hyaluronic acid binding
Polypeptides: Hyaluronan and proteoglycan link protein 3Calcium and integrin-binding protein 1
go.drugbank.com/bio_entities/BE0008691TargetHumansForms a complex with TMC6/EVER1 and TMC8/EVER2 in lymphocytes and keratynocytes where CIB1 stabilizes TMC6 and TMC8 levels and reciprocally (PubMed:30068544, PubMed:32917726) … Also promotes cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.
Polypeptides: Calcium and integrin-binding protein 1Synonyms: Calcium- and integrin-binding proteinMultidrug and toxin extrusion protein 2
go.drugbank.com/bio_entities/BE0004752TransporterHumansMediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. … Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney
Polypeptides: Multidrug and toxin extrusion protein 2Nucleolar and coiled-body phosphoprotein 1
go.drugbank.com/bio_entities/BE0005819TargetHumansprocessing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). … It has intrinsic GTPase and ATPase activities (PubMed:9016786)
Polypeptides: Nucleolar and coiled-body phosphoprotein 1Cysteine and glycine-rich protein 1
go.drugbank.com/bio_entities/BE0009098TargetHumansCould play a role in neuronal development
Polypeptides: Cysteine and glycine-rich protein 1Sodium- and chloride-dependent taurine transporter
go.drugbank.com/bio_entities/BE0009148TransporterHumansTaurine acts as an anti-aging agent by reducing cellular senescence and combating oxidative stress: levels decline with age and supplementation has been shown to extend lifespan (By similarity). … Can also mediate transport of beta-alanine, hypotaurine and gamma-aminobutyric acid (GABA) (PubMed:39837997, PubMed:40108165, PubMed:40789850, PubMed:41269860, PubMed:8010975)
Polypeptides: Sodium- and chloride-dependent taurine transporterTRAF2 and NCK-interacting protein kinase
go.drugbank.com/bio_entities/BE0009399TargetHumansMAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed … Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development.
Polypeptides: TRAF2 and NCK-interacting protein kinaseEukaryotic translation initiation factor 4E
go.drugbank.com/bio_entities/BE0000957TargetHumansfactors DDX19 and GLE1 (By similarity). … In the nucleus, binds to capped splice factor-encoding mRNAs and stimulates their nuclear export to enhance splice factor production by increasing their cytoplasmic availability to the translation machinery
Polypeptides: Eukaryotic translation initiation factor 4EFunction: DNA-binding transcription factor bindingFibroblast growth factor receptor 4
go.drugbank.com/bio_entities/BE0001203TargetHumansTyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of … Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling
Polypeptides: Fibroblast growth factor receptor 4Hypoxia-inducible factor 1-alpha
go.drugbank.com/bio_entities/BE0002374TargetHumansUnder hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose … Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042).
Polypeptides: Hypoxia-inducible factor 1-alpha