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Displaying results 121 - 125 of 125 in total
  1. Pathway

    Tyrosinemia, Transient, of the Newborn

    smpdb.ca/view/SMP0125592
    Disease

    and derivatives. … The inhibition is reversible by removal of excess substrate and by reducing agents such as ascorbic acid, 2, 6-dichiorophenolindophenol, and a number of hydroquinone and phenylenediamine compounds.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
  2. Pathway

    Dopamine beta-Hydroxylase Deficiency

    smpdb.ca/view/SMP0125594
    Disease

    Noradrenaline and adrenaline are generally not detectable in plasma, urine, and cerebrospinal fluid, but dopamine is increased 7- to 12-fold in plasma, 4-fold in urine, and 20-fold in CSF. … Treatment with dihydroxyphenylserine has been shown to reduce symptoms and signs of postural hypotension and increase plasma levels of noradrenaline.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
  3. Pathway

    Droxidopa B2-Adrenergic Artery Dilation Action Pathway

    smpdb.ca/view/SMP0126493
    Drug action

    The alpha and beta/gamma subunits of the G protein separate and GDP is replaced with GTP on the alpha subunit. … PKA also phosphorylates KCa++ channels in ASM, increasing their open-state probability (and therefore K+ efflux) and promoting hyperpolarization.

    Drugs: ATP · Norepinephrine · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
  4. Pathway

    Droxidopa A1-Adrenergic Vasoconstriction Action Pathway

    smpdb.ca/view/SMP0126494
    Drug action

    Norephinephrine acts at alpha-adrenergic receptors as a vasoconstrictor and at beta-adrenergic receptors as a heart stimulator and artery dilator. … associated symptoms of lightheadedness, dizziness, blurred vision, and syncope through the induction of tachycardia (increased heart rate) and hypertension.

    Drugs: ATP · Norepinephrine · Calcium · Magnesium cation
  5. Pathway

    Norepinephrine B2-Adrenergic Artery Dilation Action Pathway

    smpdb.ca/view/SMP0126573
    Drug action

    The alpha and beta/gamma subunits of the G protein separate and GDP is replaced with GTP on the alpha subunit. … Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter.

    Drugs: ATP · Norepinephrine · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate