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Teniposide Action Pathway
smpdb.ca/view/SMP0000443Drug actionTeniposide is a type of chemotherapy drug, derived from the epipodophyllotoxin form the American Mayapple plant. Teniposide is related to etoposide, another anti-cancer drug.
Lidocaine (Local Anaesthetic) Action Pathway
smpdb.ca/view/SMP0000398Drug actionLidocaine diffuses across the neuronal plasma membrane in its uncharged base form. … Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side.
Fluoxetine Action Pathway
smpdb.ca/view/SMP0000426Drug actionFluoxetine is a selective serotonin reuptake inhibitor that exerts antidepressive effects by selectively inhibiting serotonin reuptake in the brain. It does so by competing for the same binding site as serotonin on the the sodium-depende...
Nicotine Action Pathway
smpdb.ca/view/SMP0000431Drug actionNicotine is a stimulant drug that acts as an agonist at nicotinic acetylcholine receptors. These are ionotropic receptors composed of five homomeric or heteromeric subunits. In the brain, nicotine binds to nicotinic acetylcholine recepto...
Enzymes: Dimethylaniline monooxygenase [N-oxide-forming] 3Etoposide Metabolism Pathway
smpdb.ca/view/SMP0000601Drug metabolismEtoposide is a medication commonly sold as Vepesid, or Etopophos. It is a type of chemotherapy. It is used to treat many types of cancers, including nonlymphocytic leukemia and testicular cancer. Etoposide is semisynthetic and a derivati...
Lidocaine (Antiarrhythmic) Action Pathway
smpdb.ca/view/SMP0000328Drug actionThis pathway illustrates the lidocaine targets involved in antiarrhythmic therapy. Contractile activity of cardiac myocytes is elicited via action potentials mediated by a number of ion channel proteins. During rest, or diastole, cells m...
Codeine Action Pathway
smpdb.ca/view/SMP0000405Drug actionOpiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for...
Methadone Action Pathway
smpdb.ca/view/SMP0000408Drug actionMethadone exerts its analgesic by acting on the mu-opioid receptor of sensory neurons. Binding to the mu-opioid receptor activates associated G(i) proteins. These subsequently act to inhibit adenylate cyclase, reducing the level of intra...
Imipramine
smpdb.ca/view/SMP0000422Drug actionImipramine is a tricyclic antidepressant that exerts its therapeutic effects by inhibiting norepinephrine and serotonin reuptake in the brain. It does so by competing for the same binding site as norepinephrine on the sodium-dependent no...
Citalopram Action Pathway
smpdb.ca/view/SMP0000424Drug actionCitalopram is a selective serotonin reuptake inhibitor that exerts antidepressive effects by selectively inhibiting serotonin reuptake in the brain. It does so by competing for the same binding site as serotonin on the the sodium-depende...