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Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
go.drugbank.com/bio_entities/BE0000377TargetHumansMitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939 … Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion
Synonyms: Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenaseCytohesin-2
go.drugbank.com/bio_entities/BE0002654TargetHumansPromotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity).
Synonyms: PH, SEC7 and coiled-coil domain-containing protein 2Excitatory amino acid transporter 3
go.drugbank.com/bio_entities/BE0001054TargetTransporterHumansPlays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). … Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:21123949, PubMed:26690923, PubMed:33658209, PubMed:7521911, PubMed
Synonyms: Neuronal and epithelial glutamate transporterRibosomal protein S6 kinase alpha-4
go.drugbank.com/bio_entities/BE0004614TargetHumans/FOS and c-jun/JUN. … Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and
Synonyms: Nuclear mitogen- and stress-activated protein kinase 2Zinc transporter ZIP12
go.drugbank.com/bio_entities/BE0009897TransporterHumansMay play a role in neurulation and neurite extension. … May play a key role in maintaining intracellular zinc content at levels that reduce the inhibitory effects of rises in oxidative stress on spermatogonia and spermatozoa viability during spermatogenesis
Synonyms: Zrt- and Irt-like protein 12Zinc transporter ZIP13
go.drugbank.com/bio_entities/BE0009900TransporterHumansFunctions as a zinc transporter transporting Zn(2+) from the Golgi apparatus to the cytosol and thus influences the zinc level at least in areas of the cytosol (PubMed:21917916, PubMed:23213233).
Synonyms: Zrt- and Irt-like protein 13Zinc transporter ZIP1
go.drugbank.com/bio_entities/BE0009902TransporterHumansTransporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space (PubMed:11301334, PubMed:12888280, PubMed:16844077). Functions as the major importer of zinc from circulating blood plasma into...
Synonyms: Zrt- and Irt-like protein 1Scavenger receptor class B member 1
go.drugbank.com/bio_entities/BE0000189TargetTransporterHumansAlso facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. … Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621).
Synonyms: CD36 and LIMPII analogous 1Tumor necrosis factor ligand superfamily member 13
go.drugbank.com/bio_entities/BE0010394TargetHumansCytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes
Synonyms: TNF- and APOL-related leukocyte expressed ligand 2Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
go.drugbank.com/bio_entities/BE0021514EnzymeHumansPhosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end … Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:
Synonyms: SAM domain and HD domain-containing protein 1