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Displaying results 121 - 130 of 184 in total
  1. Target

    Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

    go.drugbank.com/bio_entities/BE0021514
    EnzymeHumans

    Phosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end … Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:

    Synonyms: SAM domain and HD domain-containing protein 1
  2. Target

    C-C motif chemokine 2

    go.drugbank.com/bio_entities/BE0001047
    TargetHumans

    Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:10587439, PubMed:9837883). … Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8195247, PubMed:8627182, PubMed:9792674).

    Synonyms: Monocyte chemotactic and activating factor
  3. Target

    Serine/threonine-protein kinase 16

    go.drugbank.com/bio_entities/BE0009542
    TargetHumans

    Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. … Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins

    Synonyms: Myristoylated and palmitoylated serine/threonine-protein kinase
  4. Target

    DNA-binding protein SMUBP-2

    go.drugbank.com/bio_entities/BE0013009
    TargetHumans

    5' to 3' helicase that unwinds both RNA and DNA duplexes in an ATP-dependent reaction (Probable) (PubMed:19158098, PubMed:30218034). … Specific to 5'-phosphorylated single-stranded guanine-rich sequences (PubMed:22999958, PubMed:8349627).

    Synonyms: DNA and RNA 5'-3' helicase IGHMBP2
  5. Target

    E3 ubiquitin ligase TRAF3IP2

    go.drugbank.com/bio_entities/BE0011632
    TargetHumans

    Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B … and MAPkinase pathways (PubMed:19825828)

    Synonyms: Connection to IKK and SAPK/JNK
  6. Target

    Amino acid transporter heavy chain SLC3A1

    go.drugbank.com/bio_entities/BE0001130
    TransporterHumans

    Associates with SLC7A13 to form a functional complex that transports anionic and neutral amino acids via exchange or facilitated diffusion. … Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine.

    Synonyms: Neutral and basic amino acid transport protein
  7. Target

    Serine/threonine-protein kinase 26

    go.drugbank.com/bio_entities/BE0004109
    TargetHumans

    Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. … STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling.

    Synonyms: MST3 and SOK1-related kinase
  8. Target

    Cytohesin-3

    go.drugbank.com/bio_entities/BE0004433
    TargetHumans

    Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity)

    Synonyms: PH, SEC7 and coiled-coil domain-containing protein 3
  9. Target

    Anoctamin-1

    go.drugbank.com/bio_entities/BE0004746
    TargetHumans

    Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. … Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC (PubMed:33026825).

    Synonyms: Tumor-amplified and overexpressed sequence 2
  10. Target

    Metal cation symporter ZIP14

    go.drugbank.com/bio_entities/BE0009903
    TransporterHumans

    May also function intracellularly and mediate the transport from endosomes to cytosol of iron endocytosed by transferrin (PubMed:20682781). … Controls the cellular uptake by the intestinal epithelium of systemic zinc, which is in turn required to maintain tight junctions and the intestinal permeability (By similarity).

    Synonyms: Zrt- and Irt-like protein 14