Search

Displaying results 121 - 130 of 597 in total
  1. Pathway

    Nalbuphine Action Pathway

    smpdb.ca/view/SMP0000691
    Drug action

    Nalbuphine (also known as Rubuphine and Nubain) is a competitive antagonist of mu-type and kappa-type opioid receptor in the central nervous system (CNS).

    Drugs: ATP · Norepinephrine · Nalbuphine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  2. Pathway

    Fosphenytoin (Antiarrhythmic) Action Pathway

    smpdb.ca/view/SMP0000326
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … The extra sodium and calcium ions that entered the cell during the action potential are extruded via sodium-potassium ATPases and NCX and intra- and extracellular ion concentrations are restored.

    Drugs: ATP · Phenytoin · Fosphenytoin · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  3. Pathway

    Diltiazem Action Pathway

    smpdb.ca/view/SMP0000359
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … The extra sodium and calcium ions that entered the cell during the action potential are extruded via sodium-potassium ATPases and NCX and intra- and extracellular ion concentrations are restored.

    Drugs: ATP · Diltiazem · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  4. Pathway

    Lidocaine (Antiarrhythmic) Action Pathway

    smpdb.ca/view/SMP0000328
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … The extra sodium and calcium ions that entered the cell during the action potential are extruded via sodium-potassium ATPases and NCX and intra- and extracellular ion concentrations are restored.

    Drugs: NADH · ATP · Lidocaine · Potassium cation · Calcium · Mesoheme +1 more
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  5. Pathway

    Mexiletine Action Pathway

    smpdb.ca/view/SMP0000329
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … The extra sodium and calcium ions that entered the cell during the action potential are extruded via sodium-potassium ATPases and NCX and intra- and extracellular ion concentrations are restored.

    Drugs: ATP · Mexiletine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  6. Pathway

    Striated Muscle Contraction

    smpdb.ca/view/SMP0000588
    Physiological

    the sodium/potassium channels to be opened. … The fast influx of sodium and slow efflux of potassium through the channel causes depolarization.

    Drugs: ATP · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  7. Pathway

    Sufentanil Action Pathway

    smpdb.ca/view/SMP0000417
    Drug action

    and decrease in cAMP production. … It also inhibits nociceptive neurotransmitter release and induces membrane hyperpolarization. Analgesia, anesthesia, and respiratory depression are a consequence of remifentanial’s action.

    Drugs: ATP · Norepinephrine · Sufentanil · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  8. Pathway

    Levorphanol Action Pathway

    smpdb.ca/view/SMP0000673
    Drug action

    The binding of levorphanol will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Therefore, levorphanol can reduce nerve conduction and decrease neurotransmitter release; so that perception of pain signals can be blocked.

    Drugs: ATP · Norepinephrine · Levorphanol · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  9. Pathway

    Methadyl Acetate Action Pathway

    smpdb.ca/view/SMP0000678
    Drug action

    The binding of methadyl acetate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Therefore, methadyl acetate can reduce nerve conduction and decrease neurotransmitter release; so that perception of pain signals can be blocked.

    Drugs: ATP · Norepinephrine · Dopamine · Potassium cation · Calcium · Methadyl acetate
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  10. Pathway

    Ethylmorphine Action Pathway

    smpdb.ca/view/SMP0000681
    Drug action

    Morphine can also bind and inhibit gamma-Aminobutyric acid (GABA) inhibitory interneurons. … Ethylmorphine (also known as codethyline and dionine) is an opioid analgesic. Ethylmorphine can be metabolized to form morphine by cytochrome P450 2D6 (CYP2D6).

    Drugs: ATP · Norepinephrine · Dopamine · Potassium cation · Calcium · Ethylmorphine
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1