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Mitogen-activated protein kinase kinase kinase kinase 1
go.drugbank.com/bio_entities/BE0009470TargetHumansSerine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a...
Synonyms: MEK kinase kinase 1Sorbitol
go.drugbank.com/drugs/DB01638ApprovedInvestigationalIt was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. … A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose.
Mixtures: MINICA S ENEMA, Cystosol W 3% HexitolsCategories: Compounds used in a research, industrial, or household settingBetaine
go.drugbank.com/drugs/DB06756ApprovedInvestigationalNutraceuticalBetaine is a methyl group donor that functions in the normal metabolic cycle of methionine. … It is a naturally occurring choline derivative commonly ingested through diet, with a role in regulating cellular hydration and maintaining cell function.
Mixtures: KORDEL`S NUTRITIME TABLET, Ultr F/b E.S. Mega Lipotropic Fmla W B6betSynonyms: 2-N,N,N-trimethylammonio acetate, N,N,N-TrimethylglycineAnthoxanthum odoratum pollen
go.drugbank.com/drugs/DB10404ApprovedAnthoxanthum odoratum pollen is the pollen of the Anthoxanthum odoratum plant. Anthoxanthum odoratum pollen is mainly used in allergenic testing.
Mixtures: T-O-S Standardized Grass Pollen Mix, T-O-S Standardized Grass Pollen MixPhenserine
go.drugbank.com/drugs/DB04892InvestigationalIf this is substantiated in an ongoing clinical trial then phenserine may open the door to an entirely new type of treatment for AD. … Phenserine is under development by Axonyx, a US biopharmaceutical company that focuses on treatments for dementia.
Categories: Heterocyclic Compounds, 2-RingPicrotoxin
go.drugbank.com/drugs/DB00466ExperimentalAlthough it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates. [PubChem] … A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the gamma-aminobutyric acid-activated chloride ionophore.
Categories: GABA-A Receptor Antagonists, Compounds used in a research, industrial, or household settingBupivacaine
go.drugbank.com/drugs/DB00297ApprovedInvestigationalBupivacaine is a widely used local anesthetic agent.
Mixtures: Mlp A-2, Mlp A-1Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesDual specificity mitogen-activated protein kinase kinase 2
go.drugbank.com/bio_entities/BE0004744TargetHumansCatalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner;...
Synonyms: MEK 2Azelastine
go.drugbank.com/drugs/DB00972ApprovedInvestigational[L8240,L8270] Azelastine is also available in combination with fluticasone propionate as a nasal spray marketed under the trade name Dymista™, which is indicated for the symptomatic treatment of seasonal … Azelastine, a phthalazine derivative, is an antihistamine available as an intranasal spray for the treatment of allergic and vasomotor rhinitis and as an ophthalmic solution for the treatment of allergic
Mixtures: N-S-4, ALERXY® CCategories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesNa(+)/citrate cotransporter
go.drugbank.com/bio_entities/BE0008677TransporterHumansHigh-affinity sodium/citrate cotransporter that mediates the entry of citrate into cells, which is a critical participant of biochemical pathways (PubMed:12445824, PubMed:12826022, PubMed:26324167, PubMed:26384929, PubMed:30054523, PubMe...
Synonyms: NACT