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Nelarabine
go.drugbank.com/drugs/DB01280ApprovedInvestigational[A2332] Due to the rarity of these T-cell malignancies, nelarabine was first granted orphan drug status and a fast-track designation by the FDA to address the unmet therapeutic needs of these cancers. … ), in both adult and pediatric patients whose disease has not responded to or has relapsed following at least two chemotherapy regimens.
Synonyms: 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purineProducts: NELARAMAX 250 MG/50 ML IV İNFÜZYONLUK ÇÖZELTİ , 6 ADET, NELARAMAX 250 MG/50 ML IV İNFÜZYONLUK ÇÖZELTİ , 1 ADETAsenapine
go.drugbank.com/drugs/DB06216ApprovedInvestigationalIt is also for severe post-traumatic stress disorder nightmares in soldiers as an off-label use. FDA approved on August 13, 2009. … Developed by Schering-Plough after its merger with Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with
Categories: Dopamine D2 Receptor Antagonists, Cytochrome P-450 SubstratesProducts: SYCREST 5MG DILALTI TABLET, 100 TABLET, SYCREST 10MG DILALTI TABLET, 100 TABLETEntacapone
go.drugbank.com/drugs/DB00494ApprovedInvestigationalof levodopa and a decarboxylase inhibitor. … Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols.
Mixtures: Pentiro 150 mg/37,5 mg/200 mg Filmtabletten, Sastravi 150 mg/37,5 mg/200 mg FilmtablettenCategories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 Enzyme InhibitorsZalcitabine
go.drugbank.com/drugs/DB00943ApprovedWithdrawnThe compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. … A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen.
Products: ZALCITABINA MK 0.75 MG, Hivid Tab 0.75 mgVinflunine
go.drugbank.com/drugs/DB11641ApprovedInvestigationalLike other vinca agents, vinflunine is an anti-mitotic agent that induces a cell cycle arrest at the G2/M phase and promotes cell death via apoptosis [L1396]. … Having an incidence of 429,700 new cases per year worldwide, urothelial carcinoma of the bladder is one of the most common malignancies that mostly affects individuals aged 50–79 years [A32626].
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexProducts: Javlor Concentrate for Solution for Infusion 25 mg/mLFoscarnet
go.drugbank.com/drugs/DB00529ApprovedInvestigationalAn antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV.
Products: FOSCAVIR INFUSION 24 mg/ml, Foscarnet Tillomed 24 mg/ml InfusionslösungEphedra sinica root
go.drugbank.com/drugs/DB01363ApprovedNutraceuticalThe sale of ephedra-containing supplements intended to increase muscle weight or promote weight loss was banned in the United States in 2004 due to the risk for adverse effects and a lack of evidence for … Ephedra is an alkaloid chemical compound traditionally obtained from the plant _Ephedra sinica_.
Mixtures: Dr. Miller's Formula No. 1Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesCoagulation factor VII human
go.drugbank.com/drugs/DB13150ApprovedInvestigationalCoagulation factor VII is human serine protease type enzyme that is involved in the extrinsic coagulation cascade which results in blood clotting.
Mixtures: COFACT 250 IU/10 ML IV ENJEKSIYON IÇIN TOZ IÇEREN FLAKON, 1 ADET, COFACT 500 IU/20 ML IV ENJEKSIYON IÇIN TOZ IÇEREN FLAKON, 1 ADETProducts: CONCENTRADO DE FACTOR VIICobamamide
go.drugbank.com/drugs/DB11191ApprovedNutraceuticalThis drug is available as a nutritional supplement to prevent vitamin B12 deficiency. Vitamin B12 is a collective term for these variously substituted corrinoids. … Vitamin B12 has important physiological roles including DNA synthesis, myelin formation in the nervous system, red blood cell formation, as well as fatty acid and amino acid metabolism [L2047].
Products: AKTİBOL 1000 MCG LİYOFİLİZE ENJEKSİYONLUK TOZ, 100 ADET, AKTIBOL 1000 MCG KAPSUL, 50 ADETBaricitinib
go.drugbank.com/drugs/DB11817ApprovedInvestigationalBaricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. … Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, MATE 2 Substrates with a Narrow Therapeutic IndexProducts: UNAMİTY 4 MG FİLM KAPLI TABLET, 7 ADET, UNAMİTY 4 MG FİLM KAPLI TABLET, 14 ADET