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Norepinephrine Alpha 1A Adrenergic Blood Vessel Relaxation Action Pathway
smpdb.ca/view/SMP0125166Drug actionIt acts on all adrenergic receptors, but the main mechanism of action is on the alpha 1A receptor in blood vessel smooth muscles, and the beta 1 receptor in heart muscles. … In the blood vessels, including the aorta, it activates an Alpha adrenergic receptor which activates the Gq protein cascade.
Enzymes: Protein kinase C alpha type, Alpha-1A adrenergic receptorIodohippurate sodium I-131 Drug Metabolism
smpdb.ca/view/SMP0130590MetabolicIodohippurate sodium I-131 passes through the liver and is then excreted from the body mainly through the kidney. … Iodohippurate sodium I-131 is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Iodohippurate sodium I-131Iodohippurate sodium I-123 Drug Metabolism
smpdb.ca/view/SMP0130602MetabolicIodohippurate sodium I-123 passes through the liver and is then excreted from the body mainly through the kidney. … Iodohippurate sodium I-123 is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Iodohippurate sodium I-123Carbamazepine Sodium Channel Analgesic Action Pathway
smpdb.ca/view/SMP0123059Drug actionIn neurons that are repetitively firing, their sodium channels are being opened more often, and as a result, carbamazepine is able to produce a greater block in these neurons. … By blocking the voltage gated sodium channels, carbamazepine prevents the depolarization phase, inhibiting action potential generation and the release of excitatory neurotransmitter like glutamate.
Enzymes: Sodium channel protein type 2 subunit alpha, Sodium channel subunit beta-2Tocainide Sodium Channel Antiepileptic Action Pathway
smpdb.ca/view/SMP0126266Drug actionTocainide is an orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels and typically used to treat ventricular arrhythmias. … In neurons that are repetitively firing, their sodium channels are being opened more often, and as a result, tocainide is able to produce a greater block in these neurons.
Enzymes: Sodium channel protein type 5 subunit alpha, Alpha-1-syntrophinMethadyl acetate Opioid Agonist Action Pathway
smpdb.ca/view/SMP0126792Drug actionMethadyl acetate is a narcotic analgesic with a long onset and duration of action, used to treat narcotic dependence. … Methadyl acetate binds to mu opioid receptors, stimulating the exchange of GTP for GDP on the G-protein complex.
Drugs: ATP · Calcium · Magnesium cation · Methadyl acetate · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit alpha-1, Guanine nucleotide-binding protein G(i) subunit alpha-1Roxatidine Acetate H2 Anti-Histamine Action Pathway
smpdb.ca/view/SMP0123168Drug actionRoxatidine Acetate is an histamine H2 receptor antagonist used to treat stomach ulcers and Gastroesophageal Reflux Disease (GERD). … After being taken orally, it is absorbed in the GI tract and travels through the blood to get to the stomach epithelium.
Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Roxatidine acetateEnzymes: Potassium-transporting ATPase alpha chain 1, cAMP-dependent protein kinase catalytic subunit alphaLidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126504Drug actionIt ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding … Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication.
Enzymes: Sodium channel protein type 5 subunit alpha, Sodium channel protein type 10 subunit alphaTocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126519Drug actionTocainide is an orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels and typically used to treat ventricular arrhythmias. … Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells.
Enzymes: Sodium channel protein type 5 subunit alpha, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency
smpdb.ca/view/SMP0125799Diseaseand sex steroids synthesis caused by a defect in the CYP17A1 gene which codes for Steroid 17-alpha-hydroxylase/17,20 lyase. … Adrenal hyperplasia type 5 (AH5) also known as Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of cortisol
Enzymes: Steroid 17-alpha-hydroxylase/17,20 lyase