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Displaying results 131 - 140 of 367 in total
  1. Target

    Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

    go.drugbank.com/bio_entities/BE0005530
    TargetHumans

    Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). … In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049).

    Polypeptides: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENSynonyms: Phosphatase and tensin homolog
  2. Target

    High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

    go.drugbank.com/bio_entities/BE0003717
    TargetHumans

    Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299) … May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167).

    Polypeptides: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
  3. Target

    Steryl-sulfatase

    go.drugbank.com/bio_entities/BE0001197
    TargetEnzymeHumans

    Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid

    Polypeptides: Steryl-sulfataseSynonyms: Steryl-sulfate sulfohydrolase, Estrone sulfatase
  4. Target

    N-acetylgalactosamine-6-sulfatase

    go.drugbank.com/bio_entities/BE0000883
    EnzymeTargetHumans

    Lysosomal enzyme that hydrolyzes sulfate groups from glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate (C6S)

    Polypeptides: N-acetylgalactosamine-6-sulfataseSynonyms: Galactose-6-sulfate sulfatase, N-acetylgalactosamine-6-sulfate sulfatase
  5. Target

    Iduronate 2-sulfatase

    go.drugbank.com/bio_entities/BE0009328
    EnzymeTargetHumans

    Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate

    Polypeptides: Iduronate 2-sulfataseSynonyms: Alpha-L-iduronate sulfate sulfatase
  6. Target

    Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

    go.drugbank.com/bio_entities/BE0018277
    TargetHumans

    Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). … Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity)

    Polypeptides: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1Synonyms: Leucine-rich repeat and immunoglobulin domain-containing protein 1
  7. Target

    Inositol 1,4,5-trisphosphate receptor

    go.drugbank.com/bio_entities/BE0004914
    TargetHumans

    Regulates fertilization and egg activation by tuning the frequency and amplitude of calcium oscillations (By similarity) … calcium, to an open state, capable of transferring calcium ions across the ER membrane (By similarity).

    Polypeptides: Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1, Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2Function: calcium ion binding, calcium channel inhibitor activity
  8. Target

    S-formylglutathione hydrolase

    go.drugbank.com/bio_entities/BE0002283
    TargetEnzymeHumans

    Serine hydrolase involved in the detoxification of formaldehyde

    Synonyms: Methylumbelliferyl-acetate deacetylase
  9. Target

    Acetyl-coenzyme A synthetase

    go.drugbank.com/bio_entities/BE0001916
    TargetSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

    Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. … Required for acetate recapture but not for acetate excretion when this organism is grown on ethanolamine (PubMed:16272400).

    Synonyms: Acetate--CoA ligaseFunction: acetate-CoA ligase activity
  10. Target

    Solute carrier family 13 member 1

    go.drugbank.com/bio_entities/BE0000022
    TransporterHumans

    Sodium:sulfate symporter that mediates sulfate reabsorption in the kidney and small intestine (PubMed:11161786, PubMed:38552027, PubMed:39576865). … Can also mediate the transport of selenate and thiosulfate (By similarity)

    Synonyms: Na(+)/sulfate cotransporter, Renal sodium/sulfate cotransporter