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Thyroxine 5-deiodinase
go.drugbank.com/bio_entities/BE0009333TargetEnzymeHumansPlays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:7593630, PubMed:12586771, PubMed:12746313, PubMed:18821722 … to 3,3',5'-triiodothyronine (rT3), 3,5,3'-triiodothyronine (T3) to 3,3'-diiodothyronine (3,3'-T2), 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine (3-T1), rT3 to 3',5'-diiodothyronine (3',5'-T2) and
Synonyms: Type III iodothyronine deiodinaseAnaerobic ribonucleoside-triphosphate reductase
go.drugbank.com/bio_entities/BE0001442TargetEnterobacteria phage T4Catalyzes the conversion of ribonucleotides into deoxyribonucleotides, which are required for DNA synthesis and repair.
Synonyms: Class III ribonucleoside-triphosphate reductaseCytochrome b-c1 complex subunit 6, mitochondrial
go.drugbank.com/bio_entities/BE0003856TargetHumansThe respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase … and the ATP synthase.
Synonyms: Complex III subunit 6, Complex III subunit VIIINADH dehydrogenase [ubiquinone] 1 subunit C2
go.drugbank.com/bio_entities/BE0000173TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis but required for the complex assembly. Complex I functions in the transfer of electrons fr...
Synonyms: Human lung cancer oncogene 1 proteinVasoactive intestinal polypeptide receptor 2
go.drugbank.com/bio_entities/BE0013151TargetHumansBinds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of potency PACAP38 = VIP > PACAP27 (PubMed:35477937, PubMed:8933357). … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors.
Synonyms: PACAP type III receptor, Pituitary adenylate cyclase-activating polypeptide type III receptorHLA class I histocompatibility antigen, A alpha chain
go.drugbank.com/bio_entities/BE0003483TargetHumansBoth the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed … Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:7504010, PubMed:9862734).
Synonyms: Human leukocyte antigen AAdiponectin receptor
go.drugbank.com/bio_entities/BE0010287TargetHumansRequired for normal glucose and fat homeostasis and for maintaining a normal body weight. … Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis.
Synonyms: Progestin and adipoQ receptor family member II, Progestin and adipoQ receptor family member 1E3 ubiquitin-protein transferase MAEA
go.drugbank.com/bio_entities/BE0003374TargetHumansCore component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor … Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (Probable)
Synonyms: Human lung cancer oncogene 10 proteinIron(3+)-hydroxamate-binding protein FhuD
go.drugbank.com/bio_entities/BE0001379TargetEscherichia coli (strain K12)Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. … Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrichrome, gallichrome, desferrioxamine, coprogen, aerobactin, shizokinen, rhodotorulic acid and the antibiotic albomycin.
Synonyms: Iron(III)-hydroxamate-binding protein FhuDApolipoproteins
go.drugbank.com/bio_entities/BE0010065CarrierTargetHumansPlays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. … A component of trypanosome lytic factor of human serum; plays a crucial role in killing Trypanosoma brucei by forming pores in parasite lysosomal membranes and sensitizing T.brucei to oxidation-stimulated
Polypeptides: Apolipoprotein C-III, Apolipoprotein A-IISynonyms: ApoC-III, ApoA-II