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Displaying results 131 - 140 of 180 in total
  1. Target

    Metal cation symporter ZIP8

    go.drugbank.com/bio_entities/BE0009901
    TransporterHumans

    Thereby, it also contributes to the cellular uptake of selenium, an essential trace metal and micronutrient (PubMed:27166256). … By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries (By similarity).

    Synonyms: Zrt- and Irt-like protein 8, BCG-induced integral membrane protein in monocyte clone 103 protein
  2. Target

    E3 ubiquitin-protein ligase CHIP

    go.drugbank.com/bio_entities/BE0021260
    TargetHumans

    -dependent monoubiquitination and leading to POLB-degradation by the proteasome (PubMed:19713937). … Likely mediates polyubiquitination and down-regulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (PubMed:28813410

    Synonyms: STIP1 homology and U box-containing protein 1
  3. Target

    Excretory Secretory (ES) proteins

    go.drugbank.com/bio_entities/BE0009630
    TargetFasciola hepatica

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. … Thiol protease that assists the parasite in burrowing through the gut wall and liver of its mammalian host.

    Synonyms: Newly excysted juvenile proteins 5 and 7
  4. Target

    Serine/threonine-protein kinase TAO2

    go.drugbank.com/bio_entities/BE0004632
    TargetHumans

    Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. … This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation

    Synonyms: Thousand and one amino acid protein kinase 2
  5. Target

    Metallo-beta-lactamase type 2

    go.drugbank.com/bio_entities/BE0001212
    TargetEnzymeBacteroides fragilis

    Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.

    Synonyms: Carbapenem and cephamycin resistance
  6. Target

    Protein O-GlcNAcase

    go.drugbank.com/bio_entities/BE0005827
    TargetHumans

    Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1 (PubMed:28939839, PubMed:37962578). … Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714)

    Synonyms: Nuclear cytoplasmic O-GlcNAcase and acetyltransferase
  7. Target

    Angiopoietin-1 receptor

    go.drugbank.com/bio_entities/BE0003379
    TargetHumans

    and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. … In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-

    Synonyms: Tyrosine kinase with Ig and EGF homology domains-2
  8. Target

    Cyclic nucleotide phosphodiesterase

    go.drugbank.com/bio_entities/BE0004922
    TargetHumans

    Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148) … Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials.

    Polypeptides: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10ASynonyms: cAMP and cGMP phosphodiesterase 11A
  9. Target

    Serine/threonine-protein kinase TAO1

    go.drugbank.com/bio_entities/BE0009392
    TargetHumans

    Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules … In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6.

    Synonyms: Thousand and one amino acid protein kinase 1
  10. Target

    TIR domain-containing adapter molecule 1

    go.drugbank.com/bio_entities/BE0016552
    TargetHumans

    Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, … Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against

    Synonyms: Proline-rich, vinculin and TIR domain-containing protein B