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SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
go.drugbank.com/bio_entities/BE0010396TargetHumansAs neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or … Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity).
Synonyms: Mitotic growth and transcription activatorGlutamate decarboxylase
go.drugbank.com/bio_entities/BE0010293TargetHumansCatalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor.
Synonyms: Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa), Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa), isoform CRA_bSerine/threonine-protein kinase DCLK2
go.drugbank.com/bio_entities/BE0009430TargetHumansProtein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. … May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity
Synonyms: Doublecortin-like and CAM kinase-like 2Hepatitis A virus cellular receptor 2
go.drugbank.com/bio_entities/BE0010551TargetHumansInhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). … Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function.
Synonyms: T-cell immunoglobulin and mucin domain-containing protein 3Tumor necrosis factor ligand superfamily member 13B
go.drugbank.com/bio_entities/BE0000999TargetHumansTogether, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. … Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors.
Synonyms: TNF- and APOL-related leukocyte expressed ligand 1E3 ubiquitin ligase TRAF3IP2
go.drugbank.com/bio_entities/BE0011632TargetHumansand MAPkinase pathways (PubMed:19825828) … Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B
Synonyms: Connection to IKK and SAPK/JNKE3 ubiquitin-protein ligase CHIP
go.drugbank.com/bio_entities/BE0021260TargetHumansUbiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation (PubMed:19567782). … Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (PubMed:27708256).
Synonyms: STIP1 homology and U box-containing protein 1Excretory Secretory (ES) proteins
go.drugbank.com/bio_entities/BE0009630TargetFasciola hepaticaThiol protease that assists the parasite in burrowing through the gut wall and liver of its mammalian host. … Thiol protease that assists the parasite in burrowing through the gut wall and liver of its mammalian host.
Synonyms: Newly excysted juvenile proteins 5 and 7Serine/threonine-protein kinase TAO2
go.drugbank.com/bio_entities/BE0004632TargetHumansIsoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. … Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases.
Synonyms: Thousand and one amino acid protein kinase 2Metallo-beta-lactamase type 2
go.drugbank.com/bio_entities/BE0001212TargetEnzymeBacteroides fragilisConfers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.
Synonyms: Carbapenem and cephamycin resistance