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Displaying results 131 - 140 of 225 in total
  1. Target

    rRNA methyltransferase 2, mitochondrial

    go.drugbank.com/bio_entities/BE0020789
    TargetHumans

    S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU … This activity may require prior 2'-O-methylguanosine modification at position 1370 (Gm1370) by MRM3 (PubMed:35177605).

    Synonyms: 16S rRNA [Um1369] 2'-O-methyltransferase, 16S rRNA (uridine(1369)-2'-O)-methyltransferaseFunction: rRNA (uridine-2'-O-ribose)-methyltransferase activity
  2. Target

    Thioredoxin reductase 1, cytoplasmic

    go.drugbank.com/bio_entities/BE0001979
    TargetEnzymeHumans

    Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation.

    Synonyms: Gene associated with retinoic and IFN-induced mortality 12 protein, Gene associated with retinoic and interferon-induced mortality 12 protein
  3. Target

    Nuclear receptor subfamily 1 group I member 2

    go.drugbank.com/bio_entities/BE0000956
    TargetHumans

    Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. … Activated by a broad range of endogenous steroids (e.g. pregnenolone, progesterone) and xenobiotics, including the antibiotic rifampicin and certain plant-derived metabolites.

    Synonyms: Steroid and xenobiotic receptor
  4. Target

    Cathepsin K

    go.drugbank.com/bio_entities/BE0003417
    TargetHumans

    May play an important role in extracellular matrix degradation. … Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH.

    Synonyms: Cathepsin O
  5. Target

    Retinol dehydrogenase 12

    go.drugbank.com/bio_entities/BE0000726
    TargetHumans

    May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:19686838). … Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol (PubMed:12226107, PubMed:15865448).

    Synonyms: All-trans and 9-cis retinol dehydrogenase
  6. Target

    Cytoplasmic tyrosine-protein kinase BMX

    go.drugbank.com/bio_entities/BE0009416
    TargetHumans

    , cell adhesion, and apoptosis. … May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells

    Synonyms: Epithelial and endothelial tyrosine kinase
  7. Target

    Myeloid zinc finger 1

    go.drugbank.com/bio_entities/BE0013131
    TargetHumans

    Binds to target promoter DNA and functions as a transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter.

    Synonyms: Zinc finger and SCAN domain-containing protein 6
  8. Target

    Lysophosphatidylcholine acyltransferase 1

    go.drugbank.com/bio_entities/BE0017259
    TargetEnzymeHumans

    Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). … Involved in the regulation of lipid droplet number and size (PubMed:25491198)

    Synonyms: 1-acylglycerol-3-phosphate O-acyltransferase, 1-acylglycerophosphocholine O-acyltransferaseFunction: 1-acylglycerol-3-phosphate O-acyltransferase activity
  9. Target

    NADPH oxidase organizer 1

    go.drugbank.com/bio_entities/BE0002423
    TargetHumans

    Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the … Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity

    Synonyms: SH3 and PX domain-containing protein 5
  10. Target

    Kinesin-like protein KIF1A

    go.drugbank.com/bio_entities/BE0003115
    TargetHumans

    The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites … Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons.

    Synonyms: Unc-104- and KIF1A-related protein