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Methotrexate Action Pathway (new)
smpdb.ca/view/SMP0126242Drug actionMethotrexate is a chemotherapeutic drug and is a folic acid derivative that inhibits many enzymes involved in nucleotide synthesis.
Ademetionine
go.drugbank.com/drugs/DB00118ApprovedInvestigationalNutraceuticalPhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Categories: Amino Acids, Amino Acids, SulfurLevoleucovorin Action Pathway
smpdb.ca/view/SMP0126269Drug actionLevoleucovorin is a folate analog, used to counter the adverse effects of folic acid antagonists. … Folic acid is necessary in order to produce purines, pyrimidines and methionine required for DNA synthesis and replication.
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Serine · Glutamic acid · Glycine · Folic acid +1 morePafolacianine Action Pathway
smpdb.ca/view/SMP0126305Drug actionPafolacianine is a folate analogue used for the treatment of ovarian cancer. It targets the folate receptor in cancer cells where they are overexpressed. Pafolacianine binds to the receptor and is absorbed via receptor-mediated endocytos...
Lometrexol
go.drugbank.com/drugs/DB12769InvestigationalLometrexol has been used in trials studying the treatment of Lung Cancer, Drug/Agent Toxicity by Tissue/Organ, and Unspecified Adult Solid Tumor, Protocol Specific.
Categories: Folic Acid Analogues, Folic Acid AntagonistsIron Dextran
go.drugbank.com/drugs/DB00893ApprovedInvestigationalVet approvedIron dextran is a dark brown, slightly viscous liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Iron Dextran is used for the treatment of patients with documented iron deficiency in which oral administ...
Mixtures: Iron Polysaccharides Folic Acid DHA, Iron Aspartate Glycinate and Polysaccharide Complex, Ascorbic Calcium, Vitamin B12, Folic Acid, Calcium Threonate and Succinic AcidFolate Metabolism
smpdb.ca/view/SMP0000053MetabolicMany countries around the world now fortify foods with folic acid to prevent such defects. … From there, dihydrofolate reductase converts folic acid into dihydrofolic acid. Dihydrofolic acid is then created into tetrahydrofolic acid through dihydrofolate reductase.
Pemetrexed Action Pathway
smpdb.ca/view/SMP0126261Drug actionPemetrexed is an antifolate, it contains a pyrrolopyrimidine base within its structure that inhibits DNA synthesis and de novo biosynthesis of nucleotides. Once inside the cell via a folate transporter, it is converted to by folylpolyglu...
Folate Malabsorption, Hereditary
smpdb.ca/view/SMP0000724DiseaseHereditary folate malabsorption, also known as folic acid transport defect, is an extremely rare inborn error of metabolism (IEM) and autosomal recessive disorder of the folate metabolism pathway.
Folate Malabsorption, Hereditary
smpdb.ca/view/SMP0125747DiseaseHereditary folate malabsorption, also known as folic acid transport defect, is an extremely rare inborn error of metabolism (IEM) and autosomal recessive disorder of the folate metabolism pathway.