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Sofosbuvir Action Pathway
smpdb.ca/view/SMP0126154Drug actionSofosbuvir is a direct-acting antiviral agent used to treat specific hepatitis C virus in combination with other anti-viral drugs Hepatitis C virus lipoviroparticles enter target hepatocytes via receptor-mediated endocytosis. The lipovir...
Pilocarpine M3 Iris Sphincter Muscle Constriction Action Pathway
smpdb.ca/view/SMP0126358Drug actionPilocarpine, commonly known as Isopto Carpine, is a muscarinic cholinergic agonist that regularly comes as an eye drop for intraocular pressure, Glaucoma, or to induce miosis. Pilocarpine is an agonist of muscarinic acetylcholine recepto...
Methacholine M3 Bronchoconstriction Action Pathway
smpdb.ca/view/SMP0126365Drug actionMethacholine is a parasympathomimetic bronchoconstrictor used to diagnose bronchial hyperreactivity in subjects who do not have clinically apparent asthma. It can be found under the brand name Provocholine. Asthma is a complex condition ...
Solifenacin M3 Bladder Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126383Drug actionSolifenacin is a muscarinic antagonist with antispasmodic properties used to treat urge urinary incontinence, urgency, and urinary frequency associated with an overactive bladder. It can be found under the brand name Vesicare. It has a l...
Fesoterodine Action Pathway
smpdb.ca/view/SMP0126387Drug actionFesoterodine is an antimuscarinic agent used in the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency. It can be found under the brand name Toviaz. Muscarinic receptors have long been the ...
Oxyphenonium Action Pathway
smpdb.ca/view/SMP0126389Drug actionOxyphenonium is a quaternary ammonium anticholinergic agent with peripheral side effects similar to those of atropine. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has ...
Clemastine H1-Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126422Drug actionClemastine is a first-generation ethanolamine H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such ...
Cevimeline M3 Salivary Gland Smooth Muscle Contraction Action Pathway
smpdb.ca/view/SMP0126681Drug actionCevimeline is a muscarinic agonist with parasympathomimetic activities that is used for the symptomatic treatment of dry mouth in patients with Sjögren's Syndrome. It can be found under the brand name Evoxac. Cevimeline is a parasympatho...
Gq Adrenergic Smooth Muscle Contraction
smpdb.ca/view/SMP0126882PhysiologicalGq protein alpha subunit is a family of heterotrimeric G protein alpha subunits. This family is also commonly called the Gq/11 (Gq/G11) family or Gq/11/14/15 family to include closely related family members. G alpha subunits may be refer...
Cinnarizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174893Drug actionCinnarizine is an anti-histaminic drug. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, al...