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E3 ubiquitin ligase TRAF3IP2
go.drugbank.com/bio_entities/BE0011632TargetHumansand MAPkinase pathways (PubMed:19825828) … Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B
Synonyms: Connection to IKK and SAPK/JNKE3 ubiquitin-protein ligase CHIP
go.drugbank.com/bio_entities/BE0021260TargetHumansUbiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation (PubMed:19567782). … Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (PubMed:27708256).
Synonyms: STIP1 homology and U box-containing protein 1Excretory Secretory (ES) proteins
go.drugbank.com/bio_entities/BE0009630TargetFasciola hepaticaThiol protease that assists the parasite in burrowing through the gut wall and liver of its mammalian host. … Thiol protease that assists the parasite in burrowing through the gut wall and liver of its mammalian host.
Synonyms: Newly excysted juvenile proteins 5 and 7Serine/threonine-protein kinase TAO2
go.drugbank.com/bio_entities/BE0004632TargetHumansIsoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. … Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases.
Synonyms: Thousand and one amino acid protein kinase 2Metallo-beta-lactamase type 2
go.drugbank.com/bio_entities/BE0001212TargetEnzymeBacteroides fragilisConfers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.
Synonyms: Carbapenem and cephamycin resistanceProtein O-GlcNAcase
go.drugbank.com/bio_entities/BE0005827TargetHumansDeglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1 (PubMed:28939839, PubMed:37962578). … Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714)
Synonyms: Nuclear cytoplasmic O-GlcNAcase and acetyltransferaseAngiopoietin-1 receptor
go.drugbank.com/bio_entities/BE0003379TargetHumansTyrosine-protein kinase that acts as a cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, … kinase and the AKT1 signaling cascades.
Synonyms: Tyrosine kinase with Ig and EGF homology domains-2Metal cation symporter ZIP8
go.drugbank.com/bio_entities/BE0009901TransporterHumansTransports an electroneutral complex composed of a divalent metal cation and two bicarbonate anions or alternatively a bicarbonate and a selenite anion (PubMed:27166256, PubMed:31699897). … Thereby, it also contributes to the cellular uptake of selenium, an essential trace metal and micronutrient (PubMed:27166256).
Synonyms: Zrt- and Irt-like protein 8Cyclic nucleotide phosphodiesterase
go.drugbank.com/bio_entities/BE0004922TargetHumansCatalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148) … The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits (PDE6G) (PubMed:20940301).
Polypeptides: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10ASynonyms: cAMP and cGMP phosphodiesterase 11ASerine/threonine-protein kinase TAO1
go.drugbank.com/bio_entities/BE0009392TargetHumansPhosphorylates MAP2K3, MAP2K6 and MARK2. … Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases.
Synonyms: Thousand and one amino acid protein kinase 1