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Displaying results 131 - 140 of 597 in total
  1. Pathway

    Pentazocine Action Pathway

    smpdb.ca/view/SMP0000686
    Drug action

    Binding of pentazocine on mu-type opioid receptor and kappa-type opioid receptor can lead to decreased level of neuronal excitability and hyperpolarization. … Pentazocine can bind to mu-type opioid receptor and kappa-type opioid receptor on neuron of central nerves system (CNS).

    Drugs: ATP · Norepinephrine · Pentazocine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  2. Pathway

    Fluoxetine Action Pathway

    smpdb.ca/view/SMP0000426
    Drug action

    It does so by competing for the same binding site as serotonin on the the sodium-dependent serotonin transporter (SLC6A4). … CREB-1 enters the nucleus and affects transcription of brain-derived neurotrophic factor (BDNF).

    Drugs: NADH · ATP · Norepinephrine · Fluoxetine · Dopamine · Potassium cation +4 more
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  3. Pathway

    Alvimopan Action Pathway

    smpdb.ca/view/SMP0000685
    Drug action

    Alvimopan is prescribed to treat patient opioid-induced constipation, a common side effect of opioid therapy. This side effect results in delayed discharge for hospitalized patients following surgery. Alvimopan helps to increase gastroin...

    Drugs: ATP · Norepinephrine · Dopamine · Potassium cation · Calcium · Alvimopan
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  4. Pathway

    Quinidine Action Pathway

    smpdb.ca/view/SMP0000323
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … The extra sodium and calcium ions that entered the cell during the action potential are extruded via sodium-potassium ATPases and NCX and intra- and extracellular ion concentrations are restored.

    Drugs: ATP · Quinidine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  5. Pathway

    Disopyramide Action Pathway

    smpdb.ca/view/SMP0000325
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … The extra sodium and calcium ions that entered the cell during the action potential are extruded via sodium-potassium ATPases and NCX and intra- and extracellular ion concentrations are restored.

    Drugs: ATP · Disopyramide · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  6. Pathway

    Verapamil Action Pathway

    smpdb.ca/view/SMP0000375
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … The extra sodium and calcium ions that entered the cell during the action potential are extruded via sodium-potassium ATPases and NCX and intra- and extracellular ion concentrations are restored.

    Drugs: ATP · Verapamil · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  7. Pathway

    Timolol Action Pathway

    smpdb.ca/view/SMP0000659
    Drug action

    Around the cell there are many transports happening through many different transporters, leading in and out of the cell Some of the transports into the cell include sodium and calcium, while transports … are also working hard to constantly export potassium from the cell.

    Drugs: ATP · Timolol · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  8. Pathway

    Atropine M2 Cardiac Muscle Contraction Action Pathway

    smpdb.ca/view/SMP0124615
    Drug action

    All of these downstream effects increase heart rate and blood pressure therefore abolishing bradycardia and low blood pressure. … Atropine is an alkaloid originating from the plant Atropa Betalldonna and can be found in some other plants. Naturally it is a racemic mixture of equal parts d-hyoscyamine and l-hyoscyamine.

    Drugs: Choline · ATP · Atropine · Potassium cation · Calcium · Magnesium cation +3 more
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  9. Pathway

    Procainamide (Antiarrhythmic) Action Pathway

    smpdb.ca/view/SMP0000324
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … The extra sodium and calcium ions that entered the cell during the action potential are extruded via sodium-potassium ATPases and NCX and intra- and extracellular ion concentrations are restored.

    Drugs: ATP · Procainamide · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  10. Pathway

    Tocainide Action Pathway

    smpdb.ca/view/SMP0000330
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … The extra sodium and calcium ions that entered the cell during the action potential are extruded via sodium-potassium ATPases and NCX and intra- and extracellular ion concentrations are restored.

    Drugs: ATP · Tocainide · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1