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Reticulon-4
go.drugbank.com/bio_entities/BE0010844TargetHumansThey influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412).
Synonyms: Neuroendocrine-specific protein C homolog, Nogo proteinCyanocobalamin reductase / alkylcobalamin dealkylase
go.drugbank.com/bio_entities/BE0002175TargetHumansCobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate (PubMed:187795...
Synonyms: Methylmalonic aciduria and homocystinuria type C proteinEndoplasmin
go.drugbank.com/bio_entities/BE0001165TargetHumansATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507).
Synonyms: Heat shock protein family C member 4, 94 kDa glucose-regulated proteinProtein C Action Pathway
smpdb.ca/view/SMP0126878Drug actionProtein C is an endogenous plasma protein, a zymogen that interacts with thrombomodulin in order to be converted to its active form. … Activated Protein C acts as a serine protease that acts by inactivating coagulation factors V and VIII, decreasing clot formation.
Enzymes: Protein CGramicidin D
go.drugbank.com/drugs/DB00027ApprovedInvestigationalGramcidin D is a heterogeneous mixture of three antibiotic compounds, gramicidins A, B and C, making up 80%, 6%, and 14% respectively all of which are obtained from the soil bacterial species Bacillus … Gramcidins are 15 residue peptides with alternating D and L amino acids, which assemble inside of the hydrophobic interior of the cellular lipid bilayer to form a β-helix.
Mixtures: Viaderm Kc Crm, Viaderm Kc OntCategories: Proteins, Membrane ProteinsCopanlisib
go.drugbank.com/drugs/DB12483ApprovedInvestigationalCopanlisib is a selective pan-Class I phosphoinositide 3-kinase (PI3K) inhibitor with preferential activity against the alpha and delta isoforms. … PI3K, a lipid kinase that activates downstream signalling pathways involved in cell survival and growth, that exists in different isoforms and is often overexpressed in hematological malignancies.
Categories: Protein Kinase Inhibitors, P-glycoprotein substrates with a Narrow Therapeutic IndexSynonyms: 2-AMINO-N-(7-METHOXY-8-(3-(MORPHOLIN-4-YL)PROPOXY)-2,3-DIHYDROIMIDAZO(1,2-C)QUINAZOLIN-5-YL(PYRIMIDINE-5-CARBOXAMIDE, 2-AMINO-N-(7-METHOXY-8-(3-MORPHOLIN-4-YLPROPOXY)-2,3-DIHYDROIMIDAZO(1,2-C)QUINAZOLIN-5-YL)PYRIMIDINE-5-CARBOXAMIDECasein
go.drugbank.com/drugs/DB10516ApprovedCasein allergenic extract is used in allergenic testing.
Synonyms: Milk proteinCategories: Proteins, Milk ProteinsTalquetamab
go.drugbank.com/drugs/DB16678ApprovedInvestigationalTalquetamab is a IgG4-PAA bispecific G protein-coupled receptor class C group 5 member D (GPRC5D)-directed CD3 T-cell engager. … It works to recruit CD3-expressing T cells to GPRC5D-expressing multiple myeloma cells to induce T-cell–mediated cytotoxicity.
Categories: Proteins, Blood ProteinsSynonyms: IMMUNOGLOBULIN G4-KAPPA/G4-LAMBDA, ANTI-(HOMO SAPIENS GPRC5D (G PROTEIN-COUPLED RECEPTOR CLASS C GROUP 5 MEMBER D)), AND ANTI-(HOMO SAPIENS CD3E (CD3 EPSILON, LEU-4)), HUMANIZED AND CHIMERIC MONOCLONAL, IMMUNOGLOBULIN G4-KAPPA/G4-LAMBDA, ANTI-(HOMO SAPIENS GPRC5D (G PROTEIN-COUPLED RECEPTOR CLASS C GROUP 5 MEMBER D)), AND ANTI-(HOMO SAPIENS CD3E (CD3 EPSILON, LEU-4)), HUMANIZED AND CHIMERIC MONOCLONALHepatitis C immune globulin (human)
go.drugbank.com/drugs/DB17813InvestigationalCategories: Proteins, Blood ProteinsSynonyms: Hepatitis C immune globulin, Hepatitis C immune globulin (human)Pegylated synthetic human c-peptide
go.drugbank.com/drugs/DB16283InvestigationalCategories: Amino Acids, Peptides, and ProteinsSynonyms: Pegylated human c-peptide, Pegylated synthetic human c-peptide