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Displaying results 131 - 140 of 1567 in total
  1. Pathway

    Ranitidine H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0122729
    Drug action

    This blocks the downstream Gs cascade which produces cyclic adenosine monophosphate (cAMP) which is an activator for the potassium-hydrogen ATPase pump (H+/K+ ATPase pump).

    Drugs: ATP · Ranitidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate
    Enzymes: Chloride anion exchanger, Potassium-transporting ATPase alpha chain 1
  2. Pathway

    Cimetidine H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0123152
    Drug action

    Cimetidine is an H2 receptor antagonist drug that is mainly used to treat peptic ulcers and heartburns. It works by acting as a competitive inhibitor and blocks the action of histamine on Histamine H2 receptors. This ultimately reduces g...

    Drugs: ATP · Cimetidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate
    Enzymes: Chloride anion exchanger, Potassium-transporting ATPase alpha chain 1
  3. Pathway

    Neuron Function

    smpdb.ca/view/SMP0000224
    Physiological

    Neurons maintain a voltage gradient across their membrane using metabolically driven ion pumps and ion channels for charge-carrying ions, including sodium (Na+), potassium (K+), chloride (Cl−), and calcium … The resting potential is restored after the sodium-potassium pump works to exchange three sodium ions out per two potassium ions in across the plasma membrane.

    Drugs: ATP · Norepinephrine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  4. Pathway

    Amiodarone Action Pathway (New)

    smpdb.ca/view/SMP0122646
    Drug action

    Amiodarone targets the cardiac myocytes where it blocks the inward rectifying potassium channels. This potassium is responsible for phase 3 of the action potential. … In the presence of amiodarone, K+ accumulates in the cell since the potassium channels are blocked by amiodarone.

    Drugs: ATP · Amiodarone · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  5. Pathway

    Dofetilide Action Pathway

    smpdb.ca/view/SMP0126189
    Drug action

    In the presence of dofetilide, K+ accumulates in the cell since the potassium channels are blocked by the drug (rectifier potassium current). … This potassium is responsible for phase 3 of the action potential. During phase 3, K+ goes out of the cell to allow repolarization.

    Drugs: ATP · Dofetilide · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  6. Pathway

    Quinidine Action Pathway (New)

    smpdb.ca/view/SMP0126282
    Drug action

    It prolongs cellular action potential by blocking sodium and potassium currents. … Quinidine also reduces repolarizing K+ currents (IKr, IKs), the inward rectifier potassium current (IK1), and the transient outward potassium current Ito, as well as the L-type calcium current ICa and

    Drugs: Quinidine · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  7. Pathway

    Metiamide H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0123167
    Drug action

    This blocks the downstream Gs cascade which produces cyclic adenosine monophosphate (cAMP) which is an activator for the potassium-hydrogen ATPase pump (H+/K+ ATPase pump).

    Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Metiamide
    Enzymes: Chloride anion exchanger, Potassium-transporting ATPase alpha chain 1
  8. Pathway

    Roxatidine Acetate H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0123168
    Drug action

    This blocks the downstream Gs cascade which produces cyclic adenosine monophosphate (cAMP) which is an activator for the potassium-hydrogen ATPase pump (H+/K+ ATPase pump).

    Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Roxatidine acetate
    Enzymes: Chloride anion exchanger, Potassium-transporting ATPase alpha chain 1
  9. Pathway

    Nizatidine H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0126776
    Drug action

    This transports hydrogen into the stomach lumen where it reacts with chloride to synthesize hydrochloric acid, a large component of gastric acid.

    Drugs: ATP · Nizatidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate
    Enzymes: Chloride anion exchanger, Potassium-transporting ATPase alpha chain 1
  10. Pathway

    Lavoltidine H2 Anti-histamine Action Pathway

    smpdb.ca/view/SMP0126790
    Drug action

    This blocks the downstream Gs cascade which produces cyclic adenosine monophosphate (cAMP) which is an activator for the potassium-hydrogen ATPase pump (H+/K+ ATPase pump).

    Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Lavoltidine
    Enzymes: Chloride anion exchanger, Potassium-transporting ATPase alpha chain 1