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Aripiprazole Serotonin Agonist Action Pathway
smpdb.ca/view/SMP0126456Drug actionAripiprazole is an atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome....
Enzymes: Sodium-dependent serotonin transporterRopinirole Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126458Drug actionRopinirole is a nonergoline dopamine agonist. used in the management in early and late Parkinson's disease. Ropinirole has a high affinity for and stimulates the post-synaptic dopamine receptors D2 in the central and peripheral nervous s...
Enzymes: Sodium-dependent dopamine transporterZiprasidone Serotonin Action Action Pathway
smpdb.ca/view/SMP0126471Drug actionZiprasidone is an atypical antipsychotic used to treat schizophrenia, bipolar mania, and acute agitation in schizophrenic patients. It also indicated improvement on the manic syndrome subscale that measures symptoms of mania such as mood...
Enzymes: Sodium-dependent serotonin transporterSulpiride Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126479Drug actionSulpiride is a substituted benzamide derivative and a selective dopamine D2 antagonist indicated to treat acute and chronic schizophrenia. Sulpiride is a selective dopamine D2 and D3 receptor antagonist.
Enzymes: Sodium-dependent dopamine transporterLoxapine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126481Drug actionLoxapine belongs to the class of first generation antipsychotics, a dibenzoxazepine compound in the subclass of tricyclic antipsychotic agents. Loxapine is a dopamine antagonist and serotonin 5-HT2 blocker.
Enzymes: Sodium-dependent dopamine transporterThioridazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126559Drug actionThioridazine is a trifluoro-methyl phenothiazine derivative. Thioridazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks alpha-adrenergic effect, depresses the release of hypothalamic and hypophyseal...
Enzymes: Sodium-dependent dopamine transporterAcepromazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126576Drug actionAcepromazine is a phenothiazine tranquilizer that blocks dopamine receptors in the CNS and depresses the reticular-activating system, resulting in sedation. Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It...
Enzymes: Sodium-dependent dopamine transporterRisperidone Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126599Drug actionRisperidone is a second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Paliperidone is the primary active me...
Enzymes: Sodium-dependent dopamine transporterProchlorperazine - Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126629Drug actionProchlorperazine is administered orally. It is a phenothiazine derivative, used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. Dopamine-antagonizing medications such as prochlorperazine are thoug...
Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Prochlorperazine · Dopamine · Levodopa +2 moreEnzymes: Sodium-dependent dopamine transporterDesvenlafaxine SNRI - Norepinephrine reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126425Drug actionThe exact mechanism of action of venlafaxine in the treatment of various psychiatric conditions has not been fully elucidated; however, it is understood that venlafaxine and its active metabolite O-desmethylvenlafaxine (ODV) commonly cal...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Venlafaxine · Norepinephrine · Dopamine +6 moreEnzymes: Sodium-dependent noradrenaline transporter