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Displaying results 1441 - 1450 of 6949 in total
  1. Target

    Tyrosine-protein phosphatase non-receptor type 11

    go.drugbank.com/bio_entities/BE0001071
    TargetHumans

    Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:14739280, PubMed:18559669 … Acts as an effector of PDCD1-mediated inhibition of T-cell response: recruited by phosphorylated PDCD1, mediating dephosphorylation of key T-cell receptor (TCR) proximal signaling molecules, leading to

    Polypeptides: Tyrosine-protein phosphatase non-receptor type 11
  2. Target

    Proto-oncogene tyrosine-protein kinase receptor Ret

    go.drugbank.com/bio_entities/BE0002411
    TargetHumans

    Also active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage (PubMed:21357690). … Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived

    Polypeptides: Proto-oncogene tyrosine-protein kinase receptor Ret
  3. Target

    Tumor necrosis factor receptor superfamily member 8

    go.drugbank.com/bio_entities/BE0003479
    TargetHumans

    Receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts.

    Polypeptides: Tumor necrosis factor receptor superfamily member 8Synonyms: CD30L receptor
  4. Target

    Parathyroid hormone/parathyroid hormone-related peptide receptor

    go.drugbank.com/bio_entities/BE0003508
    TargetHumans

    G protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:10913300, PubMed:11773434, PubMed:18375760, PubMed:19674967, PubMed:27160269, PubMed

    Polypeptides: Parathyroid hormone/parathyroid hormone-related peptide receptorSynonyms: PTH1 receptor, PTH/PTHr receptor
  5. Target

    Gamma-aminobutyric acid receptor subunit gamma-1

    go.drugbank.com/bio_entities/BE0003593
    TargetHumans

    Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790). GABA-gated chloride channels, also named GABA(A) receptors (...

    Polypeptides: Gamma-aminobutyric acid receptor subunit gamma-1Synonyms: GABA(A) receptor subunit gamma-1
  6. Target

    Gamma-aminobutyric acid receptor subunit rho-3

    go.drugbank.com/bio_entities/BE0003619
    TargetHumans

    Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (By similarity). Rho-containing GABA-gated chloride ...

    Polypeptides: Gamma-aminobutyric acid receptor subunit rho-3Synonyms: GABA(C) receptor, GABA(A) receptor subunit rho-3
  7. Target

    Acetylcholine receptor subunit alpha-type unc-63

    go.drugbank.com/bio_entities/BE0004926
    TargetCaenorhabditis elegans

    Alpha subunit of nicotinic acetylcholine receptor (nAChR) (PubMed:15280391, PubMed:15990870, PubMed:20027209).

    Polypeptides: Acetylcholine receptor subunit alpha-type unc-63
  8. Target

    G protein-coupled bile acid receptor 1

    go.drugbank.com/bio_entities/BE0005788
    TargetHumans

    G protein-coupled receptor for bile acid (PubMed:12419312, PubMed:12524422, PubMed:32698187, PubMed:32747649, PubMed:35858343).

    Polypeptides: G protein-coupled bile acid receptor 1Synonyms: G protein-coupled receptor GPCR19, Membrane-type receptor for bile acids
  9. Target

    Lymphatic vessel endothelial hyaluronic acid receptor 1

    go.drugbank.com/bio_entities/BE0010044
    TargetHumans

    Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding ...

    Polypeptides: Lymphatic vessel endothelial hyaluronic acid receptor 1Synonyms: Hyaluronic acid receptor
  10. Target

    Nuclear receptor subfamily 4immunitygroup A member 1

    go.drugbank.com/bio_entities/BE0010494
    TargetHumans

    Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652).

    Polypeptides: Nuclear receptor subfamily 4immunitygroup A member 1Synonyms: Testicular receptor 3, Orphan nuclear receptor HMR