Search

Displaying results 141 - 150 of 160885 in total
  1. Pathway

    Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency

    smpdb.ca/view/SMP0000372
    Disease

    and sex steroids synthesis caused by a defect in the CYP17A1 gene which codes for Steroid 17-alpha-hydroxylase/17,20 lyase. … Adrenal hyperplasia type 5 (AH5) also known as Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of cortisol

    Drugs: NADH · Progesterone · Hydrocortisone · Mesoheme · Cholesterol · Corticosterone +1 more
    Enzymes: Steroid 17-alpha-hydroxylase/17,20 lyase
  2. Pathway

    Sodium 1,2-Dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) Drug Metabolism

    smpdb.ca/view/SMP0130668
    Metabolic

    Sodium 1,2-Dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) passes through the liver and is then excreted from the body mainly through the kidney. … Sodium 1,2-Dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Sodium 1,2-Dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol)
  3. Pathway

    Diazoxide Drug Metabolism

    smpdb.ca/view/SMP0130712
    Metabolic

    Diazoxide passes through the liver and is then excreted from the body mainly through the kidney. … Diazoxide is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Diazoxide
  4. Pathway

    Finerenone Action Pathway

    smpdb.ca/view/SMP0126009
    Drug action

    In the principal cells of the collecting duct, sodium and water reabsorption occur, along with potassium excretion. … This effect on gene transcription leads to an upregulation of sodium channels in the apical membrane and Na+/K+ ATPase in the basolateral membrane, aiding an increase in Na+ and water reabsorption and

    Drugs: Potassium cation · Urea · Finerenone
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Amiloride-sensitive sodium channel subunit alpha
  5. Pathway

    Triamterene Action Pathway (New)

    smpdb.ca/view/SMP0126281
    Drug action

    sodium uptake and potassium secretion. … In the late distal tubule to the collecting duct, sodium ions are actively reabsorbed via ENaC on the luminal membrane and are extruded out of the cell into the peritubular medium by a sodium-potassium

    Drugs: Triamterene · Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Amiloride-sensitive sodium channel subunit alpha
  6. Pathway

    Amiloride Action Pathway (New)

    smpdb.ca/view/SMP0126243
    Drug action

    Amiloride works by inhibiting sodium reabsorption in the distal convoluted tubules and collecting ducts in the kidneys by binding to the amiloride-sensitive sodium channels, at the alpha, beta, gamma, … This promotes the loss of sodium and water from the body, but without depleting potassium.

    Drugs: Amiloride · Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Amiloride-sensitive sodium channel subunit alpha
  7. Pathway

    Eplerenone Action Pathway

    smpdb.ca/view/SMP0122731
    Drug action

    In the principal cells of the collecting duct, sodium and water reabsorption occur, along with potassium excretion. … This effect on gene transcription leads to an upregulation of sodium channels in the apical membrane and Na+/K+ ATPase in the basolateral membrane, aiding an increase in Na+ and water reabsorption and

    Drugs: Eplerenone · Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Amiloride-sensitive sodium channel subunit alpha
  8. Pathway

    Spironolactone Action Pathway (New)

    smpdb.ca/view/SMP0126006
    Drug action

    This effect on gene transcription leads to an upregulation of sodium channels in the apical membrane and Na+/K+ ATPase in the basolateral membrane, aiding an increase in Na+ and water reabsorption and … In the principal cells of the distal convoluted tubule, sodium and water reabsorption occur, along with potassium excretion.

    Drugs: Spironolactone · Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Amiloride-sensitive sodium channel subunit alpha
  9. Pathway

    Lactose Degradation

    smpdb.ca/view/SMP0000457
    Metabolic

    GLUT1 actively transports glucose and galactose with 2 sodium ions. … Alpha-Lactose is the major sugar present in milk and the main source of energy supplied to the newborn mammalian in its mother’s milk. Lactose is also an important osmotic regulator of lactation.

    Drugs: ATP · Potassium cation · Lactose
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-3
  10. Pathway

    Lactose Intolerance

    smpdb.ca/view/SMP0000458
    Disease

    Lactase deficiency is most prevalent in Asia, Africa and Indigenous populations in North and South America. … The symptoms of lactose intolerance include diarrhea, bloating, abdominal pain and excessive flatus.

    Drugs: ATP · Potassium cation · Lactose
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-3