Search
Gamma-aminobutyric acid receptor subunit delta
go.drugbank.com/bio_entities/BE0003599TargetHumansGABAARs containing delta/GABRD subunits are predominantly located in extrasynaptic or perisynaptic positions on hippocampus and cerebellar granule cells, and contribute to the tonic GABAergic inhibition … Delta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:35355020).
Polypeptides: Gamma-aminobutyric acid receptor subunit deltaAsc-type amino acid transporter 1
go.drugbank.com/bio_entities/BE0004709TransporterHumansAssociates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. … to glycinergic motor neurons (By similarity).
Polypeptides: Asc-type amino acid transporter 1Function: L-amino acid transmembrane transporter activityY+L amino acid transporter 2
go.drugbank.com/bio_entities/BE0009872TransporterHumansHeterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids … ) induction, and protein nitration (By similarity).
Polypeptides: Y+L amino acid transporter 2Synonyms: y(+)L-type amino acid transporter 2, Cationic amino acid transporter, y+ systemLysosomal acid lipase/cholesteryl ester hydrolase
go.drugbank.com/bio_entities/BE0010879EnzymeTargetHumansCatalyzes the deacylation of cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol (PubMed:15269241, PubMed:1718995, PubMed:7204383, PubMed: … Hydrolyzes triglycerides (1,2,3-triacylglycerol) and diglycerides (such as 1,2-diacylglycerol and 1,3-diacylglycerol) with preference for the acyl moieties at the sn-1 or sn-3 positions (PubMed:7204383
Polypeptides: Lysosomal acid lipase/cholesteryl ester hydrolaseSynonyms: Acid cholesteryl ester hydrolaseNeutral amino acid transporter B(0)
go.drugbank.com/bio_entities/BE0000236TargetTransporterHumansIn a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (PubMed:17094966 … The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation
Polypeptides: Neutral amino acid transporter B(0)Synonyms: Sodium-dependent neutral amino acid transporter type 2Branched-chain-amino-acid aminotransferase, cytosolic
go.drugbank.com/bio_entities/BE0000517TargetEnzymeHumansCatalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine
Polypeptides: Branched-chain-amino-acid aminotransferase, cytosolicFunction: branched-chain-amino-acid14 kDa fatty acid-binding protein
go.drugbank.com/bio_entities/BE0001566TargetBlood flukeMay play a role in the transport of fatty acids. Binds various fatty acids, such as arachidonic, oleic, palmitic and linolenic acid (in vitro).
Polypeptides: 14 kDa fatty acid-binding proteinFunction: fatty acid bindingLong-chain fatty acid transport protein
go.drugbank.com/bio_entities/BE0001610TargetEscherichia coli (strain K12)Involved in translocation of long-chain fatty acids across the outer membrane. It is a receptor for the bacteriophage T2. FadL may form a specific channel.
Polypeptides: Long-chain fatty acid transport proteinNicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
go.drugbank.com/bio_entities/BE0001809TargetHumansFor the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively … Also acts as a cofactor for glutamate and aspartate ADP-ribosylation by directing PARP1 catalytic activity to glutamate and aspartate residues on histones (By similarity).
Polypeptides: Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1Aklanonic acid methyl ester cyclase AcmA
go.drugbank.com/bio_entities/BE0003340TargetStreptomyces galilaeusCatalyzes the cyclization of aklanonic acid methyl ester to yield aklaviketone. … It is also able to use nogalonic acid methyl ester as substrate, but produces exclusively auraviketone with C9-R stereochemistry.
Polypeptides: Aklanonic acid methyl ester cyclase AcmA