Search
Adiponectin receptor
go.drugbank.com/bio_entities/BE0010287TargetHumansRequired for normal glucose and fat homeostasis and for maintaining a normal body weight. … Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis.
Synonyms: Progestin and adipoQ receptor family member 1, Progestin and adipoQ receptor family member ISolute carrier family 12 member 2
go.drugbank.com/bio_entities/BE0000281TargetTransporterHumansCation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714 … Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105)
Synonyms: Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2Solute carrier family 12 member 1
go.drugbank.com/bio_entities/BE0000502TargetTransporterHumansRenal sodium, potassium and chloride non-electrogenic ion symporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration … and volume regulation (PubMed:21321328).
Synonyms: Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1Excitatory amino acid transporter 2
go.drugbank.com/bio_entities/BE0000884TargetTransporterHumansSodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:14506254, PubMed:15265858, PubMed:26690923, PubMed:7521911). … Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity)
Synonyms: Sodium-dependent glutamate/aspartate transporter 2Acid-sensing ion channel 3
go.drugbank.com/bio_entities/BE0004768TargetHumansDisplays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:9744806, PubMed:9886053). … ASIC3 is more sensitive to protons and gates between closed, open, and desensitized states faster than other ASICs (By similarity).
Synonyms: Testis sodium channel 1Solute carrier organic anion transporter family member 1A2
go.drugbank.com/bio_entities/BE0003642TransporterHumansPlays roles in blood-brain and -cerebrospinal fluid barrier transport of organic anions and signal mediators, and in hormone uptake by neural cells (By similarity). … May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel (PubMed:23243220).
Synonyms: Sodium-independent organic anion transporterSolute carrier family 23 member 1
go.drugbank.com/bio_entities/BE0000168TransporterTargetHumansHas retained some ancestral activity toward nucleobases such as urate, an oxidized purine.
Synonyms: Sodium-dependent vitamin C transporter 1Immunoglobulin J chain
go.drugbank.com/bio_entities/BE0009083TargetHumansIn the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers.
Synonyms: Joining chain of multimeric IgA and IgMNa(+)/dicarboxylate cotransporter 3
go.drugbank.com/bio_entities/BE0000611TransporterHumansHigh-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate)
Synonyms: Sodium-dependent high-affinity dicarboxylate transporter 2Prolyl 3-hydroxylase OGFOD1
go.drugbank.com/bio_entities/BE0002210TargetHumansProlyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation
Synonyms: Termination and polyadenylation 1 homolog, 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1