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Serine/threonine-protein kinase DCLK1
go.drugbank.com/bio_entities/BE0009429TargetHumansProbable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system
Synonyms: Doublecortin-like and CAM kinase-like 1Serine/threonine-protein kinase DCLK3
go.drugbank.com/bio_entities/BE0009431TargetHumansSynonyms: Doublecortin-like and CAM kinase-like 3DNA damage-inducible transcript 4 protein
go.drugbank.com/bio_entities/BE0003445TargetHumansPlays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. … Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity).
Synonyms: Protein regulated in development and DNA damage response 1Caspase-4
go.drugbank.com/bio_entities/BE0009964TargetHumansLPS-binding promotes CASP4 activation and CASP4-mediated cleavage of GSDMD and IL18, followed by IL18 secretion through the GSDMD pore, pyroptosis of infected cells and their extrusion into the gut lumen … Also indirectly promotes secretion of mature cytokines (IL1A and HMGB1) downstream of GSDMD-mediated pyroptosis via activation of the NLRP3 and NLRP6 inflammasomes (PubMed:26375003, PubMed:32109412).
Synonyms: ICE and Ced-3 homolog 2Potassium-transporting ATPase ATP-binding subunit
go.drugbank.com/bio_entities/BE0003296TargetEscherichia coli (strain K12)This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm (PubMed:16354672, PubMed:30478378, PubMed:34272288).
Synonyms: Potassium-binding and translocating subunit BMyosin light chain 6B
go.drugbank.com/bio_entities/BE0004292TargetHumansRegulatory light chain of myosin. Does not bind calcium
Synonyms: Smooth muscle and nonmuscle myosin light chain alkali 6BEphrin type-A receptor 8
go.drugbank.com/bio_entities/BE0009440TargetHumansThe GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. … Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity)
Synonyms: EPH- and ELK-related kinasePhosphoserine phosphatase
go.drugbank.com/bio_entities/BE0004590TargetHumansMay also act on O-phospho-D-serine (Probable) … Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine (PubMed:12213811, PubMed:14673469, PubMed:15291819, PubMed
Synonyms: O-phosphoserine phosphohydrolaseZinc transporter ZIP2
go.drugbank.com/bio_entities/BE0009889TransporterHumansThe Zn(2+) uniporter activity is independent of H(+)-driving force, but is modulated by extracellular pH and membrane potential.
Synonyms: Zrt- and Irt-like protein 2N-succinylamino acid racemase
go.drugbank.com/bio_entities/BE0003211TargetDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)Catalyzes both N-succinylamino acid racemization and OSB synthesis at equivalent rates (PubMed:24872444). … Acts as a N-succinylamino acid racemase (NSAR) that catalyzes the racemization of N-succinyl-L-phenylglycine and N-succinyl-D/L-phenylalanine (PubMed:24872444, PubMed:25875730).
Synonyms: o-succinylbenzoate synthase, o-succinylbenzoic acid synthase