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Displaying results 141 - 150 of 172 in total
  1. Target

    TIR domain-containing adapter molecule 1

    go.drugbank.com/bio_entities/BE0016552
    TargetHumans

    Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, … Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against

    Synonyms: Proline-rich, vinculin and TIR domain-containing protein B
  2. Target

    E3 ubiquitin-protein ligase UHRF1

    go.drugbank.com/bio_entities/BE0018559
    TargetHumans

    Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications (PubMed:21777816). … Acts both as a histone reader and writer: specifically recognizes and binds (1) hemimethylated DNA at replication forks and (2) histone H3 trimethylated at 'Lys-9' and unmethylated at 'Arg-2' (H3K9me3

    Synonyms: Ubiquitin-like PHD and RING finger domain-containing protein 1
  3. Target

    Serine/threonine-protein kinase mTOR

    go.drugbank.com/bio_entities/BE0002386
    TargetHumans

    In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation … In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed

    Synonyms: Rapamycin and FKBP12 target 1
  4. Target

    Serine/threonine-protein kinase TAO3

    go.drugbank.com/bio_entities/BE0009393
    TargetHumans

    Promotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis (PubMed:34634521). … Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF).

    Synonyms: Thousand and one amino acid protein 3
  5. Target

    Alpha-ketoglutarate-dependent dioxygenase FTO

    go.drugbank.com/bio_entities/BE0005795
    TargetHumans

    ASB2 and RARA, leading to promote their expression (PubMed:28017614, PubMed:29249359) … Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698, PubMed:20376003).

    Synonyms: Fat mass and obesity-associated protein
  6. Target

    Aurora kinase B

    go.drugbank.com/bio_entities/BE0003404
    TargetHumans

    A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). … Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates

    Synonyms: Aurora- and IPL1-like midbody-associated protein 1
  7. Target

    E3 ubiquitin-protein ligase HUWE1

    go.drugbank.com/bio_entities/BE0016469
    TargetHumans

    Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). … Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquitination and degradation of NR1D1 (PubMed:20534529).

    Synonyms: HECT, UBA and WWE domain-containing protein 1, Homologous to E6AP carboxyl terminus homologous protein 9
  8. Target

    Aurora kinase A

    go.drugbank.com/bio_entities/BE0000991
    TargetHumans

    Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). … Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome

    Synonyms: Ipl1- and aurora-related kinase 1
  9. Target

    cDNA FLJ60754, moderately similar to Survival motor neuron protein

    go.drugbank.com/bio_entities/BE0009143
    TargetHumans

    Polypeptides: cDNA FLJ60754, moderately similar to Survival motor neuron proteinSynonyms: cDNA FLJ60754, moderately similar to Survival motor neuron protein
  10. Target

    NADPH oxidase

    go.drugbank.com/bio_entities/BE0004904
    TargetHumans

    In its active state, binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. … In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through

    Synonyms: SH3 and PX domain-containing protein 1A, SH3 and PX domain-containing protein 4