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Displaying results 141 - 150 of 204 in total
  1. Target

    S-methyl-5'-thioadenosine phosphorylase

    go.drugbank.com/bio_entities/BE0001128
    TargetHumans

    Catalyzes the phosphorolytic cleavage of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose1-phosphate (PubMed:3091600, PubMed:8687427, PubMed:10404592).

    Polypeptides: S-methyl-5'-thioadenosine phosphorylase
  2. Target

    Methyl-accepting chemotaxis protein II

    go.drugbank.com/bio_entities/BE0001434
    TargetSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

    Receptor for the attractant L-aspartate and related amino and dicarboxylic acids. Tar mediates taxis away from the repellents cobalt and nickel.

    Polypeptides: Methyl-accepting chemotaxis protein II
  3. Target

    3-methyl-2-oxobutanoate hydroxymethyltransferase

    go.drugbank.com/bio_entities/BE0001822
    TargetNeisseria meningitidis serogroup B (strain MC58)

    Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.

    Polypeptides: 3-methyl-2-oxobutanoate hydroxymethyltransferaseFunction: 3-methyl-2-oxobutanoate hydroxymethyltransferase activity
  4. Target

    Cyclic nucleotide phosphodiesterase

    go.drugbank.com/bio_entities/BE0004922
    TargetHumans

    Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148) … The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits (PDE6G) (PubMed:20940301).

    Polypeptides: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10ASynonyms: cAMP and cGMP phosphodiesterase 11A
  5. Target

    Serine/threonine-protein kinase TAO1

    go.drugbank.com/bio_entities/BE0009392
    TargetHumans

    Phosphorylates MAP2K3, MAP2K6 and MARK2. … Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases.

    Synonyms: Thousand and one amino acid protein kinase 1
  6. Target

    Aklanonic acid methyl ester cyclase AcmA

    go.drugbank.com/bio_entities/BE0003340
    TargetStreptomyces galilaeus

    , aclacinomycin T (aklavin) and aclacinomycin A (aclarubicin). … These compounds are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers.

    Polypeptides: Aklanonic acid methyl ester cyclase AcmASynonyms: Methyl aklanonate cyclase
  7. Target

    TIR domain-containing adapter molecule 1

    go.drugbank.com/bio_entities/BE0016552
    TargetHumans

    Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, … Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively

    Synonyms: Proline-rich, vinculin and TIR domain-containing protein B
  8. Target

    E3 ubiquitin-protein ligase UHRF1

    go.drugbank.com/bio_entities/BE0018559
    TargetHumans

    Acts both as a histone reader and writer: specifically recognizes and binds (1) hemimethylated DNA at replication forks and (2) histone H3 trimethylated at 'Lys-9' and unmethylated at 'Arg-2' (H3K9me3 … Also mediates histone H3 'Lys-14' and 'Lys-23' ubiquitination (H3K14ub and H3K23ub) at lower level (PubMed:24013172, PubMed:27595565).

    Synonyms: Ubiquitin-like PHD and RING finger domain-containing protein 1
  9. Target

    Alpha-ketoglutarate-dependent dioxygenase FTO

    go.drugbank.com/bio_entities/BE0005795
    TargetHumans

    RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720 … Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003).

    Synonyms: Fat mass and obesity-associated protein, tRNA N1-methyl adenine demethylase FTO
  10. Target

    Serine/threonine-protein kinase mTOR

    go.drugbank.com/bio_entities/BE0002386
    TargetHumans

    In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed … Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18497260, PubMed:18925875, PubMed:20516213

    Synonyms: Rapamycin and FKBP12 target 1