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Metoprolol Action Pathway
smpdb.ca/view/SMP0000302Drug actionMetoprolol bind to beta1-adrenergic receptors in heart and vascular smooth muscle to block the binding of other adrenergic neurotransmitters such as norepinephrine, which lead to decreased blood pressure
Pindolol Action Pathway
smpdb.ca/view/SMP0000306Drug actionBlocking beta-1 adrenergic receptor could prevent the binding of epinephrine and norepinephrine, which could efficiently reduce blood pressure and heart rate.
Imipramine
smpdb.ca/view/SMP0000625Drug metabolismHigher concentrations of norepinephrine and serotonin have also been shown to have long-term neuromodulatory effects. … Desipramine is an active metabolite and also has similar actions to imipramine on norepinephrine and serotonin reuptake.
Orphenadrine Drug Action
smpdb.ca/view/SMP0058808Drug actionIt also blocks the HERG potassium channel along with Nav1.7, Nav1.8, and Nav1.9 sodium channels, and is a norepinephrine and dopamine reuptake inhibitor.
Brexanolone Action Pathway
smpdb.ca/view/SMP0126148Drug actionallopregnanolone) in postpartum women susceptible to PPD whereas many commonly used anti-depressive medications elicit actions that may modulate the presence and activity of substances like serotonin, norepinephrine
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Progesterone · Calcium · Magnesium cation +4 moreLevomilnacipran SNRI - Serotonin Reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126386Drug actionLevomilnacipran (the more active 1S, 2R - enantiomer of milnacipran) is a serotonin and norepinephrine reuptake inhibitor (SNRI). … Such NE pain mitigation is consequently also enhanced by milnacipran's ability to enhance the presence of NE by inhibiting its reuptake via norepinephrine transporters at synaptic clefts
Duloxetine SNRI - Serotonin reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126449Drug actionIt blocks both sodium dependent serotonin and sodium dependent norepinephrine transporters from removing serotonin and norepinephrine respectively from the synaptic cleft. … In depressed individuals, serotonin and norepinephrine stimulation is low so an increase in serotonin and norepinephrine in the synapses can increase the stimulation of these receptors.
Methadone NMDA Antagonism Action Pathway
smpdb.ca/view/SMP0126457Drug actionIt has also been found tobe an agonist of kappa- and delta-opioid receptors, and an antagonist of serotonin and norepinephrine uptake receptors.
Amoxapine SSRI Action Pathway
smpdb.ca/view/SMP0126502Drug actionAmoxapine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT). … In animals, amoxapine reduced the uptake of norepinephirine and serotonin and blocked the response of dopamine receptors to dopamine. Amoxapine is not a monoamine oxidase inhibitor.
Sertraline Mechanism of Action Action Pathway New
smpdb.ca/view/SMP0126512Drug actionSertraline also has minimal effects on norepinephrine and dopamine uptake, and research has shown that it has more dopaminergic activity than other medications in the same SSRI class.