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Displaying results 141 - 150 of 296 in total
  1. Target

    Organic cation/carnitine transporter 2

    go.drugbank.com/bio_entities/BE0000106
    TargetTransporterHumans

    In intestinal epithelia, transports the quorum-sensing pentapeptide CSF (competence and sporulation factor) from B.subtilis which induces cytoprotective heat shock proteins contributing to intestinal homeostasis … Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine.

    Synonyms: High-affinity sodium-dependent carnitine cotransporter
  2. Target

    Acid-sensing ion channel 1

    go.drugbank.com/bio_entities/BE0000353
    TargetTransporterHumans

    Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and … Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:21036899).

    Synonyms: Brain sodium channel 2Function: ligand-gated sodium channel activity
  3. Target

    Solute carrier family 12 member 3

    go.drugbank.com/bio_entities/BE0000419
    TargetTransporterHumans

    Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules (PubMed:18270262, PubMed:21613606, PubMed:22009145 … Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2 (By similarity).

    Synonyms: Thiazide-sensitive sodium-chloride cotransporter
  4. Target

    Excitatory amino acid transporter 1

    go.drugbank.com/bio_entities/BE0001115
    TargetTransporterHumans

    Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515, … Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940).

    Synonyms: Sodium-dependent glutamate/aspartate transporter 1
  5. Target

    Linear primary-alkylsulfatase

    go.drugbank.com/bio_entities/BE0003744
    TargetPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

    Alkylsulfatase that cleaves both short and medium-length alkylsulfates, including the widely used detergent sodium dodecyl sulfate (SDS) (PubMed:16684886). … Acts in vitro on primary alkylsulfates such as decyl sulfate, octyl sulfate and hexyl sulfate, but not on sulfated sugars and arylsulfates (PubMed:16684886, PubMed:23061549).

    Synonyms: Sodium dodecyl sulfate hydrolase
  6. Target

    Propionyl-CoA carboxylase alpha chain, mitochondrial

    go.drugbank.com/bio_entities/BE0000492
    TargetHumans

    valine and other metabolites (PubMed:6765947, PubMed:8434582). … subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and

    Synonyms: Propanoyl-CoA:carbon dioxide ligase subunit alpha
  7. Target

    Adiponectin receptor

    go.drugbank.com/bio_entities/BE0010287
    TargetHumans

    Required for normal glucose and fat homeostasis and for maintaining a normal body weight. … Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis.

    Synonyms: Progestin and adipoQ receptor family member 1, Progestin and adipoQ receptor family member I
  8. Target

    Solute carrier family 12 member 2

    go.drugbank.com/bio_entities/BE0000281
    TargetTransporterHumans

    Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714 … Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105)

    Synonyms: Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
  9. Target

    Solute carrier family 12 member 1

    go.drugbank.com/bio_entities/BE0000502
    TargetTransporterHumans

    Renal sodium, potassium and chloride non-electrogenic ion symporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration … and volume regulation (PubMed:21321328).

    Synonyms: Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
  10. Target

    Excitatory amino acid transporter 2

    go.drugbank.com/bio_entities/BE0000884
    TargetTransporterHumans

    Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:14506254, PubMed:15265858, PubMed:26690923, PubMed:7521911). … Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity)

    Synonyms: Sodium-dependent glutamate/aspartate transporter 2