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Displaying results 141 - 150 of 178 in total
  1. Target

    Histone-lysine N-methyltransferase SETD7

    go.drugbank.com/bio_entities/BE0002524
    TargetHumans

    Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (PubMed:16141209). … Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed:12588998, PubMed:16141209).

  2. Target

    Mitogen-activated protein kinase 13

    go.drugbank.com/bio_entities/BE0003391
    TargetHumans

    MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells

  3. Target

    Somatostatin receptor type 2

    go.drugbank.com/bio_entities/BE0003528
    TargetHumans

    Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization

  4. Target

    Adenylate cyclase type 5

    go.drugbank.com/bio_entities/BE0003733
    TargetHumans

    Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569)

  5. Target

    Chymotrypsin-like elastase family member 2A

    go.drugbank.com/bio_entities/BE0003747
    TargetHumans

    Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity … Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism.

  6. Target

    Ribosomal protein S6 kinase alpha-1

    go.drugbank.com/bio_entities/BE0004274
    TargetHumans

    In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). … Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292).

  7. Target

    [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

    go.drugbank.com/bio_entities/BE0004284
    TargetHumans

    Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade.

  8. Target

    [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

    go.drugbank.com/bio_entities/BE0004348
    TargetHumans

    Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability.

  9. Target

    ADP-ribosylation factor-like protein 1

    go.drugbank.com/bio_entities/BE0004535
    TargetHumans

    thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin

  10. Target

    Serotonin Receptors

    go.drugbank.com/bio_entities/BE0004862
    TargetHumans

    Plays a role in insulin sensitivity and glucose homeostasis (By similarity)