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Displaying results 1511 - 1520 of 10000 in total
  1. Drug

    Mavelertinib

    go.drugbank.com/drugs/DB16228
    Investigational

    Mavelertinib is under investigation in clinical trial NCT02349633 (Study for Patients With NSCLC EGFR Mutations (Del 19 or L858R +/- T790M)).

  2. Indication

    Severe Glabellar Frown Lines (GL)

    go.drugbank.com/conditions/DBCOND0146865
    Drugs: Botulinum toxin type A · DaxibotulinumtoxinA
    Synonyms: Severe Glabellar Frown Lines (GL)
  3. Drug

    Teniposide

    go.drugbank.com/drugs/DB00444
    ApprovedInvestigational

    This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. … Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.

    Categories: Topoisomerase II InhibitorsSynonyms: 4'-demethylepipodophyllotoxin 9-(4,6-O-(R)-2-thenylidene-beta-D-glucopyranoside)
  4. Target

    DNA damage-inducible transcript 4 protein

    go.drugbank.com/bio_entities/BE0003445
    TargetHumans

    Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). … Plays a role in neuronal cell death

    Synonyms: Protein regulated in development and DNA damage response 1
  5. Drug

    Calcium ascorbate

    go.drugbank.com/drugs/DB14483
    ApprovedNutraceutical

    Mixtures: Supplements De Vitamines Et Mineraux, Vc IICategories: Compounds used in a research, industrial, or household setting
  6. Drug

    Sacubitril

    go.drugbank.com/drugs/DB09292
    ApprovedInvestigational

    Sacubitril is a prodrug neprilysin inhibitor used in combination with valsartan to reduce the risk of cardiovascular events in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection … II.

  7. Drug

    Sugemalimab

    go.drugbank.com/drugs/DB16641
    ApprovedInvestigational

    [L53333] In combination with platinum-based chemotherapy, sugemalimab is a first-line treatment indicated for adult populations with metastatic non-small cell lung cancer (NSCLC) with no sensitising EGFR … [L32868, L32873, L53333] The antibody is produced in Chinese hamster ovary cells by recombinant DNA technology.

  8. Target

    Nuclear factor NF-kappa-B p105 subunit

    go.drugbank.com/bio_entities/BE0001086
    TargetHumans

    NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. … the enhancer region of genes involved in immune response and acute phase reactions.

    Synonyms: Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  9. Drug

    Human papillomavirus type 6 L1 capsid protein antigen

    go.drugbank.com/drugs/DB10299
    ApprovedInvestigational

    Human papillomavirus type 6 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. … The vaccine is prepared from the purified virus-like particles (VLPs) of the major capsid (L1) protein of HPV Types 6, 11, 16, and 18, which are produced by separate fermentations in recombinant *Saccharomyces

    Mixtures: GARDASIL® 9 VACUNA RECOMBINANTE NONAVALENTE CONTRA EL VIRUS DEL PAPILOMA HUMANO, GARDASIL® 9 VACUNA RECOMBINANTE NONAVALENTE CONTRA EL VIRUS DEL PAPILOMA HUMANO
  10. Drug

    Lutein

    go.drugbank.com/drugs/DB00137
    ApprovedNutraceutical

    In green plants, xanthophylls act to modulate light energy and serve as non-photochemical quenching agents to deal with triplet chlorophyll (an excited form of chlorophyll), which is overproduced at very … Lutein is synthesized only by plants and like other xanthophylls is found in high quantities in green leafy vegetables such as spinach, kale and yellow carrots.