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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
go.drugbank.com/bio_entities/BE0000631TargetHumansCan hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10373451, PubMed:10393245, PubMed:17389385, PubMed:27058447). … May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition (PubMed:27058447)
Polypeptides: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2
go.drugbank.com/bio_entities/BE0002203TargetHumansPolypeptides: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
go.drugbank.com/bio_entities/BE0005824TargetHumansKey adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530 … Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:11847341, PubMed:29229647).
Polypeptides: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Phenolphthalein
go.drugbank.com/drugs/DB04824ApprovedWithdrawnPhenolphthalein was withdrawn in Canada due to concerns with carcinogenicity in 1997.
Categories: Indicators and Reagents, Alimentary Tract and MetabolismProducts: Feen-A-mint Phenolphthalein Tab 100mg, EX-lax Chocolated Tab 95mgBiotin
go.drugbank.com/drugs/DB00121ApprovedInvestigationalNutraceuticalIt occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.
Mixtures: B Complex 25mg Vitamin Supplement, Iron 25mg With Vit B-cmplx, Vit C, Cu & MoCategories: Enzymes and Coenzymes, Diet, Food, and NutritionCefamandole nafate
go.drugbank.com/drugs/DB14725ApprovedWithdrawnProducts: Mandol Add-vantage Inj 1gm/vialMolsidomine
go.drugbank.com/drugs/DB09282ApprovedWithdrawnMolsidomine is an orally active, long-acting vasodilator, which belongs to the class of medications known as syndnones.
Products: CORVATON 2MGDenosumab
go.drugbank.com/drugs/DB06643ApprovedInvestigationalTwo denosumab biosimilars—Wyost® (denosumab-bbdz) [L53063] and Jubbonti® (denosumab-bbdz)[L53058]—were approved by the FDA in March 2024 for all indications of the reference products Xgeva® and Prolia® … [A263071] Chemically, it consists of 2 heavy and 2 light chains, with each light chain consisting of 215 amino acids and each heavy chain consisting of 448 amino acids with 4 intramolecular disulfides.
Categories: Amino Acids, Peptides, and Proteins, Drugs Affecting Bone Structure and MineralizationProducts: XGEVA 120mg Solution for Injection, Prolia Solution for Injection 60mg Pre-filled SyringeNebivolol
go.drugbank.com/drugs/DB04861ApprovedInvestigational[A182579] Nebivolol and other beta blockers are generally not first line therapies as many patients are first treated with thiazide diuretics. … [A182579] Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol].
Mixtures: NEBITENS PLUS 5/25MG FILM TABLET, TABLET, 28 ADET, NEBITENS PLUS 5/25MG FILM TABLET, TABLET, 84 ADETCategories: valsartan and nebivolol, nebivolol and thiazidesAcute Bacterial Skin and Skin Structure Infection (ABSSSI)
go.drugbank.com/conditions/DBCOND0132808Drugs: Ceftaroline fosamil · Dalbavancin · Delafloxacin · Omadacycline · Tedizolid · Tedizolid phosphateSynonyms: Bacterial infection of skin and subcutis, Acute Bacterial Skin and Skin Structure Infections