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Displaying results 1571 - 1580 of 10000 in total
  1. Indication

    Post Nasal Drip

    go.drugbank.com/conditions/DBCOND0039260
    Drugs: DL-Methylephedrine
    Synonyms: Discharge from nasopharynx, Discharge from back of nose
  2. Target

    General transcription and DNA repair factor IIH helicase/translocase subunit XPB

    go.drugbank.com/bio_entities/BE0012820
    TargetHumans

    The structure of the TFIIH transcription complex differs from the NER-TFIIH complex; large movements by XPD/ERCC2 and XPB/ERCC3 are stabilized by XPA (PubMed:31253769, PubMed:33902107). … The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening; it may wrap around the damaged DNA wedging it open, causing localized melting that allows XPD/ERCC2 helicase

    Polypeptides: General transcription and DNA repair factor IIH helicase/translocase subunit XPB
  3. Drug

    Flavoxate

    go.drugbank.com/drugs/DB01148
    Approved

    A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. … It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. [PubChem]

    Categories: Genito Urinary System and Sex Hormones, Drugs for Urinary Frequency and IncontinenceProducts: UROXATE TABLET 100MG, U-SPA
  4. Indication

    Arrhythmia caused by Combined magnesium and potassium deficiency

    go.drugbank.com/conditions/DBCOND0138932
    Drugs: Potassium hydrogen DL-aspartate
    Synonyms: Arrhythmia caused by Combined magnesium and potassium deficiency
  5. Drug

    Magnesium sulfate

    go.drugbank.com/drugs/DB00653
    ApprovedInvestigationalVet approved

    Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083) … A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia.

    Mixtures: Magnesium Sulfate In 5% Dextrose Inj(20mg/ml), Tis-U-SolCategories: Alimentary Tract and Metabolism, Blood and Blood Forming Organs
  6. Drug

    Tretinoin

    go.drugbank.com/drugs/DB00755
    ApprovedInvestigationalNutraceutical

    [A257689] It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth … and differentiation.

    Mixtures: Clindamycin Phosphate and Tretinion, OLIVIA QUIDO FIRM and FADE ICategories: Cell Stimulants and Proliferants, Antineoplastic and Immunomodulating Agents
  7. Drug

    Sugammadex

    go.drugbank.com/drugs/DB06206
    ApprovedInvestigational

    Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015. … Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery.

    Products: BRIDION 100MG/ML SOLUTION FOR INJECTION, Bridion Solution For Injection 100mg/ml
  8. Indication

    Refractory, metastatic hormone-refractory Prostate cancer

    go.drugbank.com/conditions/DBCOND0025647
    Drugs: Docetaxel
    Synonyms: Metastasis from hormone-refractory prostate cancer, Metastasis from hormone-refractory prostate cancer (disorder)
  9. Drug

    Potassium Iodide

    go.drugbank.com/drugs/DB06715
    ApprovedInvestigational

    Saturated solution of Potassium Iodide (SSKI) is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperthyroidism (also known as thyroid storm or thyrotoxic crisis). SSKI can also be used for radi...

    Mixtures: Prenatal Vitamin-mineral Supplement Folic 5mg, Trace Minerals Et/and B12 TabCategories: Cough and Cold Preparations
  10. Target

    Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

    go.drugbank.com/bio_entities/BE0005530
    TargetHumans

    Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433). … Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase

    Polypeptides: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENSynonyms: Phosphatase and tensin homolog