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Aromatase Deficiency
smpdb.ca/view/SMP0125782DiseaseSymptoms of decrease in estrogen and increase androgens such as testosterone can cause impaired female sexual development, unusual bone growth, insulin resistance, and a variety of other symptoms. … Aromatase converts androgens to estrogens which is vital for bone growth and regulation of blood sugar levels.
Enzymes: Steryl-sulfataseBevantolol Beta Blocker Cardiac Action Pathway
smpdb.ca/view/SMP0122915Drug actionBevantolol is a beta blocker and calcium channel blocker. It is an oral drug used for the treatment of angina pectoris and hypertension. … Protein kinase is required to activate calcium channels in the cell membrane, causing them to open and allow Ca2+ to enter the cell.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GArbutamine Action Pathway
smpdb.ca/view/SMP0123258Drug actionProtein kinase activates calcium channels in the membrane, causing them to open and allow Ca2+ to enter the cell. Due to this effect, there is high concentration of Ca2+ in the cell. … is available, bronchospasm occurring during anesthesia, and as an adjunct to in the treatment of hypovolemic and septic shock, low cardiac output states, congestive heart failure, and cardiogenic shock
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GAlprenolol Action Pathway
smpdb.ca/view/SMP0124510Drug actioncAMP, PKA, SRC and nitric oxide synthase signaling. … Alprenolol also reduce sympathetic activity and is used to treat hypertension, angina, migraine headaches, and hypertrophic subaortic stenosis.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GAtenolol Action Pathway (New)
smpdb.ca/view/SMP0126183Drug actionIt can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. … cAMP, PKA, SRC and nitric oxide synthase signaling.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GBetaxolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126185Drug actionIt can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. … cAMP, PKA, SRC and nitric oxide synthase signaling.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GBisoprolol Action Pathway (New)
smpdb.ca/view/SMP0126186Drug actionIt can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. … cAMP, PKA, SRC and nitric oxide synthase signaling.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GLabetalol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126203Drug actioncAMP, PKA, SRC and nitric oxide synthase signaling. … It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GEphedrine B1-Adrenergic Cardiac Muscle Constriction Action Pathway
smpdb.ca/view/SMP0126497Drug actionProtein kinase activates calcium channels in the membrane, causing the channels to open and allow Ca2+ into the cell. … and the stimulation of beta-2-adrenergic receptors causes vasodilation and bronchodilation.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GLevobunolol Action Pathway
smpdb.ca/view/SMP0124528Drug actioncAMP, PKA, SRC and nitric oxide synthase signaling. … It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G