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Metabolism and Physiological Effects of p-Cresol sulphate
smpdb.ca/view/SMP0126850MetabolicUremic toxins include other low-molecular-weight compounds such as indoxyl sulfate, 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid, and asymmetric dimethylarginine. … The reversible reaction of l-tyrosine with 2-oxoglutarate in 4-hydroxyphenylpyruvate and L-glutamate is catalysed by tyrosine transaminase (EC 2.6.1.5.) or by aromatic-amino-acid transaminase (EC 2.6.1.57
Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
smpdb.ca/view/SMP0000309SignalingThis receptor is also thought to have roles in anxiety, appetite, GI motility, learning, memory, mood, and respiration. … The 5-HT4 receptor is primarily found in the CNS, GI tract, and PNS.
Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
smpdb.ca/view/SMP0000311SignalingThe 5-HT7 receptor is primarily found in the CNS, GI tract, and blood vessels. It is involved in thermoregulation, circadian rhythm, learning and memory, and sleep. … effectors that lead to a specific cellular response.
Metabolism and Physiological Effects of N-Acetyl-1-Methylhistidine
smpdb.ca/view/SMP0126802MetabolicN-Acetyl-1-methylhistidine belongs to the class of organic compounds known as histidine and derivatives. … Higher circulating levels of five of these N-acetylated amino acids, namely, N-δ-acetylornithine, N-acetyl-1-methylhistidine, N-acetyl-3-methylhistidine, N-acetylhistidine, and N2,N5-diacetylornithine,
Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
smpdb.ca/view/SMP0000312SignalingThe 5-HT6 receptor is primarily expressed in the brain and is involved in glutamatergic and cholinergic neuronal activity. … effectors that lead to a specific cellular response.
Metabolism and Physiological Effects of Trimethylamine N-oxide (TMAO)
smpdb.ca/view/SMP0123192MetabolicThis trimethylamine then enters a liver hepatocyte through portal circulation and gets metabolized by FMO3 to form TMAO. … First choline obtained from choline rich foods such as eggs or meat enter the gut and get metabolized to trimethylamine by gut microbes.
Enzymes: Dimethylaniline monooxygenase [N-oxide-forming] 3Metabolism and Physiological Effects of N-Acetyl-L-Alanine
smpdb.ca/view/SMP0126554MetabolicN-Acetyl-L-alanine can also be classified as an alpha amino acid or a derivatized alpha amino acid. … Technically, N-alpha-Acetyl-L-alanine is a biologically available N-terminal capped form of the proteinogenic alpha amino acid L-alanine.
Drugs: AlanineLong Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) (Fatty Acid Metabolism)
smpdb.ca/view/SMP0125740DiseaseTo help control acute episodes, treatment includes maintaining a high carbohydrate and low fat diet, and avoiding fasting for more than 12 hours. … Patients will also be at risk for hypertrophic cardiomyopathy and other heart conditions from age two months to two years.
Drugs: Adenosine phosphate · NADH · ATP · Levocarnitine · Magnesium cation · Flavin adenine dinucleotide +2 moreEnzymes: Long-chain-fatty-acid--CoA ligase 1Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
smpdb.ca/view/SMP0000333SignalingIn the ovary, the FSH receptor is necessary for follicular development and is expressed on the granulosa cells. … effectors that lead to a specific cellular response.
Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin
smpdb.ca/view/SMP0000338SignalingLHCGRs are found in the ovary, testis, and many extragonadal tissues.In the ovary, the LHCG receptor is necessary for follicular maturation and ovulation, as well as luteal function. … In the male the LHCGR has been identified on the Leydig cells that are critical for testosterone production, and support spermatogenesis.