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Displaying results 151 - 160 of 180 in total
  1. Target

    Fatty acid metabolism regulator protein

    go.drugbank.com/bio_entities/BE0004232
    TargetEscherichia coli (strain K12)

    Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE (PubMed:9388199). … Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the

    Synonyms: oleR
  2. Target

    Angiopoietin-2

    go.drugbank.com/bio_entities/BE0010028
    TargetHumans

    Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). … In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896).

    Synonyms: ANG-2
  3. Target

    Angiopoietin-1

    go.drugbank.com/bio_entities/BE0010681
    TargetHumans

    and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. … Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme

    Synonyms: ANG-1
  4. Target

    Rho-related GTP-binding protein RhoB

    go.drugbank.com/bio_entities/BE0003572
    TargetHumans

    Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. … Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.

    Synonyms: Rho cDNA clone 6
  5. Target

    Transforming protein RhoA

    go.drugbank.com/bio_entities/BE0001190
    TargetHumans

    It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. … Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle (PubMed

    Synonyms: Rho cDNA clone 12
  6. Target

    Pyruvate kinase PKM

    go.drugbank.com/bio_entities/BE0000088
    TargetHumans

    The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263) … The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed

    Synonyms: OIP-3
  7. Target

    Aminoglycoside nucleotidyltransferase (4')

    go.drugbank.com/bio_entities/BE0003547
    EnzymeStaphylococcus aureus

    Inactivates the antibiotic kanamycin by catalyzing the transfer of a nucleotidyl group from nucleoside triphosphates such as ATP to the 4'-hydroxyl group of the aminoglycoside.

    Synonyms: ANT(4')
  8. Target

    Angiopoietin-related protein 3

    go.drugbank.com/bio_entities/BE0010034
    TargetHumans

    The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface … Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol (PubMed:12565906).

    Synonyms: ANG-5
  9. Target

    Natriuretic peptides B

    go.drugbank.com/bio_entities/BE0000979
    TargetHumans

    Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:1672777, PubMed:17349887, PubMed:17372040, PubMed … Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed

    Synonyms: Iso-ANP
  10. Target

    ADP/ATP translocase 3

    go.drugbank.com/bio_entities/BE0000624
    TargetHumans

    Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:15033708). … ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).

    Synonyms: ANT 2, ANT 3