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Nylidrin Action Pathway
smpdb.ca/view/SMP0126575Drug actionVascular smooth muscle has β2-adrenoceptors that have a high binding affinity for circulating epinephrine and a lower affinity to norepinephrine released by sympathetic adrenergic nerves.
Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate · NylidrinOxprenolol B2-Adrenergic Vasoconstriction Action Pathway
smpdb.ca/view/SMP0126584Drug actionLike propranolol and timolol, oxprenolol binds at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting the effects of the catecholamines epinephrine and norepinephrine and decreasing
Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Oxprenolol · Cyclic adenosine monophosphateMethamphetamine Serotonin Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126619Drug actionLike norepinephrine the methods are less tested than for dopamine. … The mechanisms in which methamphetamine acts on serotonin are very similar to that of dopamine and norepinephrine in the presynaptic neuron.
Selegiline Action Pathway
smpdb.ca/view/SMP0126719Drug actionThe first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine. … The second one, the B isoform, breakdowns phenylethylamine, norepinephrine, epinephrine, dopamine, and tyramine. This isoform is found in the extracellular tissues and mostly in the brain.
Flibanserin Serotonin Action Action Pathway
smpdb.ca/view/SMP0126786Drug actionIts action on neurotransmitter receptors may contribute to reduction in serotonin levels and increase in dopamine and norepinephrine levels, all of which may play part in reward processing.
Quetiapine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126799Drug actionIn bipolar depression and major depression, quetiapine's actions may be attributed to the binding of this drug or its metabolite to the norepinephrine transporter.
Tapentadol Opioid Agonist Action Pathway
smpdb.ca/view/SMP0126806Drug actionTapentadol is a synthetic analgesic opioid with dual mechanism of action as a mu opioid agonist, and a norepinephrine reuptake inhibtor. It is an agonist of mu, kappa, and delta opioid receptors.
Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid · Pyrophosphoric acid +2 moreQuetiapine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126827Drug actionIn bipolar depression and major depression, quetiapine's actions may be attributed to the binding of this drug or its metabolite to the norepinephrine transporter.
Gq Muscarinic Smooth Muscle Contraction
smpdb.ca/view/SMP0126945PhysiologicalAgonists (norepinephrine, angiotensin II, endothelin, etc.) binding to serpentine receptors, coupled to a heterotrimeric G protein, stimulate phospholipase C activity.
Nomifensine Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0127002Drug actionNomifensine stimulates the nervous system through the reuptake of norepinephrine and dopamine, which prolongs their duration in the synapse so that they can bind more readily to the receptors.