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Amlodipine Action Pathway
smpdb.ca/view/SMP0000376Drug actionAmlodipine inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle to bind calmodulin. … Amlodipine has arterial selectivity due to alternative splicing of the channel and has little effect on cardiac muscle.
Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1Nitrendipine Action Pathway
smpdb.ca/view/SMP0000382Drug actionWithout calcium ions in muscle cell, calmodulin couldn't form the calcium-bound calmodulin, which is required for binding and activating MLCK. … Lack of initial influx of calcium can also reduce the level of contractile activity of muscle cells and results in vasodilation, which ultimately lead to overall decresing in blood pressure.
Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1Amiodarone Action Pathway
smpdb.ca/view/SMP0000665Drug actionThe drug inhibits Na,K-activated myocardial adenosine triphosphatase, calcium and potassium channels and beta adrenergic receptors causing an increase in ventricular and atrial muscle action duration. … Amiodarone is unique to other class III antiarrhythmic drugs due to its effect on beta adrenergic receptors, calcium channels and sodium channels.
Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1Alprenolol Action Pathway
smpdb.ca/view/SMP0000297Drug actionWithout renin, angiotensin II and aldosterone could not be produced, which ultimately prevent water retention and vasoconstriction. … Blocking beta-1 adrenergic receptor could prevent the binding of epinephrine and norepinephrine, which could efficiently reduce blood pressure and heart rate.
Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1Betaxolol Action Pathway
smpdb.ca/view/SMP0000299Drug actionBlocking of beta1-adrenergic receptors in heart and vascular smooth muscle can lead to reduced heart rate, cardiac output, and decreased blood pressure. … Betaxolol (also known as Betoptic or Lokren) is a selective beta blocker that can block beta1-adrenergic receptors and beta2-adrenergic receptors.
Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1Nadolol Action Pathway
smpdb.ca/view/SMP0000303Drug actionheart rate and cardiac output. … In juxtaglomerular apparatus, nadolol can prevent the production of aldosterone and angiotensin II by inhibiting renin production, which lead to prevention of water retention and vasoconstriction.
Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1Oxprenolol Action Pathway
smpdb.ca/view/SMP0000304Drug action, heart rate and cardiac output. … In juxtaglomerular apparatus, oxprenolol can prevent the production of aldosterone and angiotensin II by inhibiting renin production, which lead to prevention of water retention and vasoconstriction.
Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1Propranolol Action Pathway
smpdb.ca/view/SMP0000307Drug actionPropranolol binding reduces resting heart rate, cardiac output, blood pressure and orthostatic hypotension. Propranolol also reduce sympathetic activity to manage hyperthyroidism, anxiety and tremor. … Propranolol also competes for beta(2)-adrenergic receptors on bronchial and vascular smooth muscles.
Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1Nebivolol Action Pathway
smpdb.ca/view/SMP0000366Drug actionNebivolol (also known as Bystolic or Nebivololum) is a β1-receptor blocker (selective β1-receptor antagonist) that can bind and inhibit Beta-1 adrenergic receptor in muscule and heart. … Nebivolol competes with epinephrine or other beta-1 adrenergic receptor activator to bind on the receptor, which can reduce the heart rate and blood pressure that could caused by biniding of epinephrine
Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1Nifedipine Action Pathway
smpdb.ca/view/SMP0000379Drug actionWithout calcium ions in muscle cell, calmodulin couldn't form the calcium-bound calmodulin, which is required for binding and activating MLCK. … Nifedipine (also known as Adalat or Procardia) is a dihydropyridine calcium channel blocker that may be used for treatment of hypertension and exertion-related angina in the absence of vasospasm.
Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1