Search

Displaying results 151 - 160 of 298 in total
  1. Target

    Gastric inhibitory polypeptide receptor

    go.drugbank.com/bio_entities/BE0011012
    TargetHumans

    This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

    Synonyms: Glucose-dependent insulinotropic polypeptide receptor
  2. Target

    Bifunctional purine biosynthesis protein ATIC

    go.drugbank.com/bio_entities/BE0001240
    TargetEnzymeHumans

    Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571) … Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775).

  3. Target

    Cell adhesion molecule CEACAM1

    go.drugbank.com/bio_entities/BE0000107
    TargetHumans

    Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). … Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis.

  4. Target

    ATP-binding cassette sub-family C member 8

    go.drugbank.com/bio_entities/BE0000207
    TargetTransporterHumans

    Regulator subunit of pancreatic ATP-sensitive potassium channel (KATP), playing a major role in the regulation of insulin release.

  5. Target

    Alpha-2A adrenergic receptor

    go.drugbank.com/bio_entities/BE0000289
    TargetHumans

    Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release (PubMed:2568356, PubMed:27376152).

  6. Target

    ALK tyrosine kinase receptor

    go.drugbank.com/bio_entities/BE0000359
    TargetHumans

    MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction

  7. Target

    Putative hydrolase DDAH2

    go.drugbank.com/bio_entities/BE0000608
    TargetHumans

    Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity).

  8. Target

    Monocarboxylate transporter 1

    go.drugbank.com/bio_entities/BE0000669
    TargetTransporterHumans

    concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). … Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with

  9. Target

    5'-AMP-activated protein kinase catalytic subunit alpha-1

    go.drugbank.com/bio_entities/BE0000677
    TargetHumans

    Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity).

  10. Target

    Tumor necrosis factor

    go.drugbank.com/bio_entities/BE0000704
    TargetHumans

    Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. … Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity).